The effect of different norepinephrine administration methods on hypotension after spinal anesthesia in caesarean sections

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dc.contributor.authorGülhas, Nurçın
dc.contributor.authorOzkan, Ahmet Selim
dc.contributor.authorDüz, Senem Arda
dc.contributor.authorArslan, Ahmet Kadir
dc.contributor.authorSeyhun, Nurşen
dc.date.accessioned2026-04-04T13:14:36Z
dc.date.available2026-04-04T13:14:36Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractWe aimed to evaluate the effect of different routes of norepinephrine (NE) administration on maternal hypotension in pregnant females undergoing spinal anesthesia for caesarean section. 208 pregnant women were divided randomly into 4 groups (n=52). Bolus 4 μg/ml NE was administered intravenous (iv) immediately after spinal anesthesia in Group PB (Prophylactic Bolus). In Group PI (Prophylactic Infusion), 1 ml of saline solution was applied promptly after spinal anesthesia and then the NE infusion was started at 1 ml/min. In Group TB (Treatment Bolus), 1 ml Physiological Saline (PS) was administered after 1 ml/min infusion of PS immediately after spinal anesthesia and then 1 ml/min NE bolus when blood pressure decreased by 20% after the entry. In Group TBI (Treatment Bolus Infusion), 1 ml PS was administered after 1 ml/min infusion of PS immediately after spinal anesthesia, 1 ml NE and then 1 ml/min NE infusion was initiated when blood pressure decreased by 20% after the entry. At the 4th, 6th, and 8th minutes, the PI Group exhibited higher systolic and mean blood pressures than the other groups (p<.001). Additionally, hypotension was statistically lower in the PI Group than in PB, TB, TBI groups (p<.001), and episodes of hypotension, ephedrine required and extra NE boluses given were statistically lower in the PI Group than in the other groups (p<.001). Umbilical vein (UV) pH values were lower in the TBI Group at compared to the other groups (p<.001). It is suggested that a prophylactic infusion of 4 μg/min of NE in the prevention of hypotension following spinal anesthesia for cesarean section will reduce the possibility of maternal hypotension and better maintain fetal well-being than a prophylactic bolus, a treatment bolus or a posttreatment bolus infusion at the same dose.
dc.identifier.doi10.5455/medscience.2024.06.062
dc.identifier.endpage712
dc.identifier.issn2147-0634
dc.identifier.issue3
dc.identifier.startpage706
dc.identifier.trdizinid1282507
dc.identifier.urihttps://doi.org/10.5455/medscience.2024.06.062
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1282507
dc.identifier.urihttps://hdl.handle.net/11616/107318
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectAnestezi
dc.titleThe effect of different norepinephrine administration methods on hypotension after spinal anesthesia in caesarean sections
dc.typeArticle

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