Global gene expression profiling in congenital diaphragmatic hernia (CDH) patients

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridUnver, Turgay/0000-0001-6760-443X
dc.authoridKOÇ, AHMET/0000-0003-3484-2137
dc.authoridDundar, Muhammed/0000-0001-6509-2012
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidUnver, Turgay/B-4819-2009
dc.authorwosidKOÇ, AHMET/ABI-3322-2020
dc.authorwosidDundar, Muhammed/AAN-1831-2020
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidGökçe, İsmail Kürşad/ABI-8128-2020
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorDundar, Muhammed
dc.contributor.authorUnver, Turgay
dc.contributor.authorAkpinar, Necmettin
dc.contributor.authorGokce, Ismail Kursad
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorDemircan, Mehmet
dc.date.accessioned2024-08-04T20:51:45Z
dc.date.available2024-08-04T20:51:45Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCongenital diaphragmatic hernia (CDH) is an anomaly characterized by a defect in the diaphragm, leading to the passage of intra-abdominal organs into the thoracic cavity. Herein, the presented work analyzes the global gene expression profiles in nine CDH and one healthy newborn. All of the patients had left posterolateral (Bochdalek) diaphragmatic hernia, operated via an abdominal approach, and stomach and bowels in the thorax cavity. Some patients also had additional anomalies. A total of 560 differentially regulated genes were measured. Among them, 11 genes showed significant changes in expression associated with lung tissue, vascular structure development, and vitamin A metabolism, which are typical ontologies related to CDH etiology. Among them, SLC25A24 and RAB3IL1 are involved in angiogenesis, HIF1A and FOXC2-AS1 are related with the alveolus, MAGI2-AS3 is associated with the diaphragm, LHX4 and DHH are linked with the lung, and BRINP1, FZD9, WNT4, and BLOC1S1-RDH5 are involved in retinol. Besides, the expression levels of some previously claimed genes with CDH etiology also showed diverse expression patterns in different patients. All these indicated that CDH is a complex, multigenic anomaly, requiring holistic approaches for its elucidation.en_US
dc.description.sponsorshipInonu University Scientific Research Project Coordination Unit [TSA-2021-2454]en_US
dc.description.sponsorshipThis work was supported by Inonu University Scientific Research Project Coordination Unit (project code: TSA-2021-2454).en_US
dc.identifier.doi10.1007/s10142-022-00837-9
dc.identifier.endpage369en_US
dc.identifier.issn1438-793X
dc.identifier.issn1438-7948
dc.identifier.issue3en_US
dc.identifier.pmid35260975en_US
dc.identifier.scopus2-s2.0-85125944938en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://doi.org/10.1007/s10142-022-00837-9
dc.identifier.urihttps://hdl.handle.net/11616/100522
dc.identifier.volume22en_US
dc.identifier.wosWOS:000766070900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofFunctional & Integrative Genomicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCongenital diaphragmatic herniaen_US
dc.subjectGlobal transcriptomeen_US
dc.subjectVitamin Aen_US
dc.subjectMultigenicen_US
dc.titleGlobal gene expression profiling in congenital diaphragmatic hernia (CDH) patientsen_US
dc.typeArticleen_US

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