The activities of serum adenosine deaminase and xanthine oxidase enzymes in Behcet's disease

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082;
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidAydin, Erdinc/AAM-7917-2020
dc.contributor.authorSögüt, S
dc.contributor.authorAydin, E
dc.contributor.authorElyas, H
dc.contributor.authorAksoy, N
dc.contributor.authorÖzyurt, H
dc.contributor.authorTotan, Y
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:13:10Z
dc.date.available2024-08-04T20:13:10Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to Uric acid, respectively. AD is known to be an important enzyme in the maturation and function of T lymphocytes. The aim of this prospective study was to evaluate whether there are changes in serum AD activity as an index of T lymphocyte function in Behcet's disease (BD) which is known as having T cell-mediated immune response. Methods: A total of 32 patients and 26 sex- and age-matched healthy control subjects were analysed for AD and XO activities. The patients with BD were divided into two subgroups: BD with and without eye lesions. Twelve patients with complete BD and four patients with incomplete BD had eye complications. AD and XO activities in serum were measured with spectrophotometric methods. Re vults: There was a remarkable increase in AD activity and moderate increase in XO in patients with BD compared to controls indicating T cell activation and increased maturation. Serum AD activity of complete BD was higher than that of incomplete BD. There was no difference it) XO activity between the subgroups of BD. Significant positive correlation was found between AD and XO in BD, although there was no correlation in control group. Conclusions: The results indicate that increased AD and XO activities may provide an additional benefit for the diagnosis of BD and subtyping of the disease as having eye complication or not and complete and incomplete BD. Further studies are needed to bring to light the exact mechanism of AD and XO activity elevation. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S0009-8981(02)00278-4
dc.identifier.endpage138en_US
dc.identifier.issn0009-8981
dc.identifier.issue1-2en_US
dc.identifier.pmid12367777en_US
dc.identifier.scopus2-s2.0-0036843961en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1016/S0009-8981(02)00278-4
dc.identifier.urihttps://hdl.handle.net/11616/93448
dc.identifier.volume325en_US
dc.identifier.wosWOS:000178978600016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectadenosine deaminaseen_US
dc.subjectxanthine oxidaseen_US
dc.titleThe activities of serum adenosine deaminase and xanthine oxidase enzymes in Behcet's diseaseen_US
dc.typeArticleen_US

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