Effects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicity

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dc.contributor.authorAkgül, Nadir Bilgin
dc.contributor.authorÜremiş, Muhammed Mehdi
dc.contributor.authorÜremiş, Nuray
dc.contributor.authorAnnaç, Ebru
dc.contributor.authorBozat, Rıfat Cesur
dc.contributor.authorKoca, Murat
dc.contributor.authorÖzkaya, Ahmet
dc.date.accessioned2024-08-04T19:42:31Z
dc.date.available2024-08-04T19:42:31Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: In this study, it was aimed to investigate the protective effect of the synthesized coumarin ethyl 7-hydroxy-2-imino-2H-chromene-3 carboxylate (CM) against the renal toxicity of Bisphenol A (BPA). Materials and Methods: The CM molecule was synthesised through the reaction between 2,4-dihydroxybenzaldehyde and ethyl cyanoacetate. Experiment was conducted in four groups of rats: control, BPA, CM, and BPA+CM. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), and Malondialdehyde (MDA) levels in kidney tissue were evaluated. serum samples were analyzed for Total-Native thiol and kidney function test parameters. Results: The BPA-treated group exhibited significant decreases in TAS and thiol levels, increases in TOS and MDA levels. However, these side effects were significantly reduced with CM. Conclusion: results obtained in this study indicate that CM molecule has a protective effect against BPA induced kidney toxicity.en_US
dc.identifier.doi10.30569/adiyamansaglik.1373918
dc.identifier.endpage9en_US
dc.identifier.issn2458-9179
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid1231926en_US
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.1373918
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1231926
dc.identifier.urihttps://hdl.handle.net/11616/88403
dc.identifier.volume10en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of ethyl 7-hydroxy-2-imino-2H-chromene-3-carboxylate, a synthesized coumarin derivative, on bisphenol A-induced kidney toxicityen_US
dc.typeArticleen_US

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