Relationship of urocortin 2 with systolic and diastolic functions and coronary artery disease an observational study
Yükleniyor...
Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The urocortin (Ucn) hormones have many important roles in the cardiovascular system. Apart from systolic dysfunction (SD), there
is no sufficient data on the relationship between serum Ucn-2 and diastolic dysfunction (DD), or coronary artery disease (CAD). We investigated
serum Ucn-2 levels in SD, DD, and CAD.
Methods: In this observational cross-sectional study, study population was enrolled among outpatients who underwent coronary angiography
with the pre-diagnosis of CAD. By examining the echocardiography 86 subjects were selected to study after coronary angiography. The subjects
distributed over three groups to investigate the relationship between serum Ucn-2 and SD according to their ejection fraction (EF): subjects
with moderate to severe SD (Group A, EF=33.6%), subjects with mild to moderate SD (Group B, EF=46.1%), and those without SD (Group C,
EF=64.5%). Apart from these groups, the serum Ucn-2 levels were compared between subjects with and without DD (EF≥45%), and also compared
between subjects with and without CAD (EF≥55%). Statistical analyses were performed using one-way ANOVA, Kruskal-Wallis, Chisquare,
Mann-Whitney U, Spearman correlation and multiple regression analyses tests.
Results: Serum Ucn-2 levels were decreased in Group A and were increased in Group B compared to Group C (9.4±3.4, 12.8±3.6 vs. 10.4±3.9 pg/
mL, respectively, p=0.003). Unlike SD; there was no significant difference in serum Ucn-2 levels between subjects with and without DD (11.4±4.1
vs 11.7±3.9 pg/mL, p=0.8) or CAD (10.7±4.7 vs 10.2±3.2 pg/mL, p=0.7).
Conclusion: Ucn-2 is elevated in mild to moderate SD. But, DD (impaired relaxation pattern), or CAD (without myocardial infarction) seems to
have no effect on Ucn-2 hormone levels.
Açıklama
Anahtar Kelimeler
Urocortin 2, Left ventricular systolic and diastolic dysfunction, Coronary artery disease, Regression analysis
Kaynak
Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
2
Künye
Topal, E. Yağmur, J. Otlu, B. Ataş, H. Cansel, M. Açıkgöz, N. Ermiş, N. (2012). Relationship of urocortin 2 with systolic and diastolic functions and coronary artery disease an observational study . Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology, 12(2), 115–120.
