Relationship of urocortin 2 with systolic and diastolic functions and coronary artery disease an observational study

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dc.authorid101949en_US
dc.contributor.authorTopal, Ergün
dc.contributor.authorYağmur, Jülide
dc.contributor.authorOtlu, Barış
dc.contributor.authorAtaş, Halil
dc.contributor.authorCansel, Mehmet
dc.contributor.authorAçıkgöz, Nusret
dc.contributor.authorErmiş, Necip
dc.date.accessioned2017-07-15T07:03:54Z
dc.date.available2017-07-15T07:03:54Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The urocortin (Ucn) hormones have many important roles in the cardiovascular system. Apart from systolic dysfunction (SD), there is no sufficient data on the relationship between serum Ucn-2 and diastolic dysfunction (DD), or coronary artery disease (CAD). We investigated serum Ucn-2 levels in SD, DD, and CAD. Methods: In this observational cross-sectional study, study population was enrolled among outpatients who underwent coronary angiography with the pre-diagnosis of CAD. By examining the echocardiography 86 subjects were selected to study after coronary angiography. The subjects distributed over three groups to investigate the relationship between serum Ucn-2 and SD according to their ejection fraction (EF): subjects with moderate to severe SD (Group A, EF=33.6%), subjects with mild to moderate SD (Group B, EF=46.1%), and those without SD (Group C, EF=64.5%). Apart from these groups, the serum Ucn-2 levels were compared between subjects with and without DD (EF≥45%), and also compared between subjects with and without CAD (EF≥55%). Statistical analyses were performed using one-way ANOVA, Kruskal-Wallis, Chisquare, Mann-Whitney U, Spearman correlation and multiple regression analyses tests. Results: Serum Ucn-2 levels were decreased in Group A and were increased in Group B compared to Group C (9.4±3.4, 12.8±3.6 vs. 10.4±3.9 pg/ mL, respectively, p=0.003). Unlike SD; there was no significant difference in serum Ucn-2 levels between subjects with and without DD (11.4±4.1 vs 11.7±3.9 pg/mL, p=0.8) or CAD (10.7±4.7 vs 10.2±3.2 pg/mL, p=0.7). Conclusion: Ucn-2 is elevated in mild to moderate SD. But, DD (impaired relaxation pattern), or CAD (without myocardial infarction) seems to have no effect on Ucn-2 hormone levels.en_US
dc.identifier.citationTopal, E. Yağmur, J. Otlu, B. Ataş, H. Cansel, M. Açıkgöz, N. Ermiş, N. (2012). Relationship of urocortin 2 with systolic and diastolic functions and coronary artery disease an observational study . Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology, 12(2), 115–120.en_US
dc.identifier.endpage120en_US
dc.identifier.issn1302-8723
dc.identifier.issue2en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://hdl.handle.net/11616/7380
dc.identifier.volume12en_US
dc.language.isoenen_US
dc.publisherAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiologyen_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrocortin 2en_US
dc.subjectLeft ventricular systolic and diastolic dysfunctionen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectRegression analysisen_US
dc.titleRelationship of urocortin 2 with systolic and diastolic functions and coronary artery disease an observational studyen_US
dc.title.alternativeÜrocortin-2 ile sistolik, diyastolik fonksiyonlar ve koroner arter hastalığının ilişkisi: Gözlemsel bir çalışmaen_US
dc.typeArticleen_US

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