Dexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure duration

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dc.authoridErdil, Feray Akgül/0000-0002-7544-3717
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorBegec, Z.
dc.contributor.authorToprak, H. I.
dc.contributor.authorDemirbilek, S.
dc.contributor.authorErdil, F.
dc.contributor.authorOnal, D.
dc.contributor.authorErsoy, M. O.
dc.date.accessioned2024-08-04T20:30:39Z
dc.date.available2024-08-04T20:30:39Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: This study was designed to evaluate the effect of dexmedetomidine on the acute hyperdynamic response, duration of seizure activity and recovery times in patients undergoing electroconvulsive therapy (ECT). Methods: Fourteen patients underwent a total of 84 ECT sessions as a crossover design. Patients were randomly allocated to receive either dexmedetomidine (1 mu g/kg IV over a period of 10 min) or saline (control). Anaesthesia was induced with propofol 1 mg/kg, and then succinylcholine 0.5 mg/kg IV was administered. Arterial blood pressure and heart rate (HR) were recorded during the study period. Results: HR in the dexmedetomidine group was lower than that in the control group at 5 and 10 min after the start of study drug infusion, and at 1, 3 and 10 min after the seizure ended (P < 0.05). Peak HR was lower in the dexmedetomidine group compared with that in the control group (P < 0.05). The mean arterial pressure (MAP) values in the dexmedetomidine group were lower at 0, 1, 3 and 10 min after the seizure ended compared with the control group (P < 0.05). Both motor and electroencephalography (EEG) seizure duration in the control group (35.65 +/- 14.89 and 49.07 +/- 9.94 s, respectively) were similar to that in the dexmedetomidine group (33.30 +/- 12.01 and 45.15 +/- 17.79 s, respectively) (P > 0.05). Time to spontaneous breathing, eye opening and obeying commands were not different between the groups. Conclusion: A dexmedetomidine dose of 1 mu g/kg IV administered over 10 min before the induction of anaesthesia with propofol may be useful in preventing the acute hyperdynamic responses to ECT without altering the duration of seizure activity and recovery time.en_US
dc.identifier.doi10.1111/j.1399-6576.2007.01462.x
dc.identifier.endpage306en_US
dc.identifier.issn0001-5172
dc.identifier.issn1399-6576
dc.identifier.issue2en_US
dc.identifier.pmid17976228en_US
dc.identifier.scopus2-s2.0-38149142327en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage302en_US
dc.identifier.urihttps://doi.org/10.1111/j.1399-6576.2007.01462.x
dc.identifier.urihttps://hdl.handle.net/11616/94426
dc.identifier.volume52en_US
dc.identifier.wosWOS:000252391900021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Anaesthesiologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectelectroconvulsive therapyen_US
dc.subjectseizure durationen_US
dc.subjecthaemodynamic processen_US
dc.subjectdexmedetomidineen_US
dc.subjectpropofolen_US
dc.titleDexmedetomidine blunts acute hyperdynamic responses to electroconvulsive therapy without altering seizure durationen_US
dc.typeArticleen_US

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