The effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injury

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dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authoridPOLAT, Cemal/0000-0002-1587-3934
dc.authoridsabuncuoglu, mehmet zafer/0000-0002-5549-4023
dc.authorwosidAykac, Asli/AAM-9673-2020
dc.authorwosidBAHAR, LEYLA/P-3890-2015
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidPolat, Cemal/AAX-9226-2020
dc.authorwosidBAHAR, LEYLA/Y-3908-2019
dc.authorwosidÇakır, Tuğrul/AAD-1906-2019
dc.authorwosidBasturk, Ahmet/V-9914-2017
dc.contributor.authorCakir, T.
dc.contributor.authorPolat, C.
dc.contributor.authorBasturk, A.
dc.contributor.authorGul, M.
dc.contributor.authorAslaner, A.
dc.contributor.authorDurgut, H.
dc.contributor.authorSehirli, A. O.
dc.date.accessioned2024-08-04T20:41:12Z
dc.date.available2024-08-04T20:41:12Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The purpose of this study is to determine the antioxidant and anti-inflammatory effects of alpha lipoic acid (ALA) on methotrexate (MTX) induced kidney injury in rats. MATERIALS AND METHODS: Thirty-two rats were equally divided into four groups; control, ALA, MTX and MTX with ALA groups. A single dose of MTX (20 mg/kg) was administered to make kidney injury to groups 3 and 4, intraperitoneally. The ALA was administered intraperitonealy in groups 2 and 4 and the other groups received saline injection for five days. On the sixth day the blood samples and kidney tissues were obtained for the measurement of TNF-alpha, IL-1 beta, malondialdehyde, glutathione, myeloperoxidase and sodium potassium-adenosine triphosphatase levels and histological examination. RESULTS: Administration of MTX caused a decrease in tissue GSH, and Na+, K+-ATPase activity significantly. A significant increase in tissue MDA and MPO activities were also seen. The pro-inflammatory cytokines (TNF-alpha, IL-beta) were increased in the MTX group significantly. ALA treatment reversed all biochemical indices as well as histopathological alterations induced by MTX administration. CONCLUSIONS: MTX made oxidative damage on kidneys of rat and it was partially prevented by anti-inflammatory and antioxidant effects of ALA treatment.en_US
dc.identifier.endpage2139en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid26125279en_US
dc.identifier.scopus2-s2.0-84942233757en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2132en_US
dc.identifier.urihttps://hdl.handle.net/11616/96980
dc.identifier.volume19en_US
dc.identifier.wosWOS:000357615400030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectMethotrexateen_US
dc.subjectKidneyen_US
dc.subjectOxidative injuryen_US
dc.titleThe effect of alpha lipoic acid on rat kidneys in methotrexate induced oxidative injuryen_US
dc.typeArticleen_US

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