Comparison of immunological, histological and oxidative effects of felbamate and levetiracetam in traumatic brain injury

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dc.authoridBASAK, NITAI/0000-0002-6539-8609
dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridGurbuz, Sukru/0000-0003-2616-0304
dc.authorwosidBASAK, NITAI/Y-4752-2019
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidGurbuz, Sukru/ABI-3276-2020
dc.contributor.authorBayhan, I
dc.contributor.authorTurtay, M. G.
dc.contributor.authorCiftci, O.
dc.contributor.authorCetin, A.
dc.contributor.authorBasak, N.
dc.contributor.authorOztanir, M. Namik
dc.contributor.authorOguzturk, H.
dc.date.accessioned2024-08-04T20:48:44Z
dc.date.available2024-08-04T20:48:44Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: We aimed to compare immunological, histological and oxidative effects of antiepileptic agents; felbamate and levetiracetam on head trauma in rats. MATERIALS AND METHODS: In this study, 32 Sprague-Dawley genus male rats were used. A closed head trauma mechanism was constituted in order to perform head trauma in rats. Rats were divided into 4 groups, and each group had 8 rats. Following head trauma, Group 1 (Control); normal saline was administered, Group 2; levetiracetam 50 mg/kg was administered, Group 3; felbamate 100 mg/kg was administered, and Group 4; levetiracetam 50 mg/kg and felbamate 100 mg/kg were administered with a combination. Injections were administered intraperitoneally once a day for 20 days. The rats were decapitated at the end of the 20th day. Blood and tissue samples were collected and analyzed for biochemical, immunohistochemical and histological parameters. RESULTS: Serum cytokine levels in Group 2, 3 and 4 were lower when compared to the control group. In Group 4, in which combined therapy was performed, cytokine levels were found to be the lowest. In Groups 2 and 3, a significant decrease in vascular congestion, mononuclear cell infiltration, hemorrhage, and neural degeneration was noticed in the pia mater. In Group 2, a decrease in vascular congestion and Purkinje cell degeneration was obtained in the cerebellum. However, the best outcomes were determined in Group 4. CONCLUSIONS: We determined that levetiracetam and felbamate alone are useful with respect to immunological, oxidative and histological alterations. However, their utility is better when used in a combination.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2015/45]en_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Projects Unit (Project No: 2015/45).en_US
dc.identifier.endpage7091en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid32633403en_US
dc.identifier.scopus2-s2.0-85087630371en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7083en_US
dc.identifier.urihttps://hdl.handle.net/11616/99400
dc.identifier.volume24en_US
dc.identifier.wosWOS:000544032800073en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHead traumaen_US
dc.subjectFelbamateen_US
dc.subjectLevetiracetamen_US
dc.subjectRaten_US
dc.titleComparison of immunological, histological and oxidative effects of felbamate and levetiracetam in traumatic brain injuryen_US
dc.typeArticleen_US

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