Evaluation of teratogenic and toxic effects of enrofloxacin-based antibiotic on zebrafish (Danio rerio) larvae with biochemical and developmental markers

Basit Öğe Kaydı
dc.authoridturhan, duygu ozhan/0000-0002-7111-4289
dc.authorwosidturhan, duygu ozhan/AAA-3247-2021
dc.contributor.authorOzhan Turhan, Duygu
dc.date.accessioned2024-08-04T20:50:39Z
dc.date.available2024-08-04T20:50:39Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the effects of enrofloxacin-based antibiotic (EBA) used as a drug in veterinary medicine were evaluated on zebrafish embryos and larvae. The embryos were exposed to 17.56-300 mg L--(1) EBA for 96 h and survival rates and body malformations were evaluated under a stereo-microscope. In addition, 10-days larvae were exposed to LC50/4, LC50/2 and LC50 concentrations of antibiotic for 72 h and activities of glutathione S-transferase (GST), glutathione reductase, carboxylesterase, acetylcholinesterase, lactate dehydrogenase (LDH) and aspartate aminotransferases (AST) were measured. LC50 and EC50 values and the teratogenic index (TI) were calculated as 150.1 and 124.8 mg L--(1) and 1.2, respectively. EBA was teratogen for zebrafish embryos according to calculated TI. Spinal curvature, tail malformation, pericardial oedema and yolk sac oedema were determined in embryos exposed to 88.8 mg L--(1) and higher EBA concentrations. Furthermore, significant growth inhibitions were determined in larvae exposed to 59.26 mg L--(1) and above EBA concentrations. Also, 75 and 150 mg L--(1) concentrations of EBA caused a significant increase in GST, LDH and AST activities in zebrafish larvae. These results show that EBA causes adverse effects on zebrafish development and may adversely affect the aquatic ecosystem if it enters the aquatic environment.en_US
dc.identifier.doi10.1080/02757540.2021.1974007
dc.identifier.endpage714en_US
dc.identifier.issn0275-7540
dc.identifier.issn1029-0370
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85114470723en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage704en_US
dc.identifier.urihttps://doi.org/10.1080/02757540.2021.1974007
dc.identifier.urihttps://hdl.handle.net/11616/100195
dc.identifier.volume37en_US
dc.identifier.wosWOS:000693126900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofChemistry and Ecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectZebrafishen_US
dc.subjectantibioticen_US
dc.subjectenrofloxacinen_US
dc.subjecttoxicityen_US
dc.subjectbiomarkeren_US
dc.titleEvaluation of teratogenic and toxic effects of enrofloxacin-based antibiotic on zebrafish (Danio rerio) larvae with biochemical and developmental markersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu