Pioneering electrochemical detection unveils erdafitinib: a breakthrough in anticancer agent determination

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dc.authoridDuygulu, Ozgur/0000-0001-8646-0363
dc.authoridBouali, Wiem/0009-0004-5096-6804
dc.authorwosidDuygulu, Ozgur/A-9076-2015
dc.authorwosidGENC, Asena Ayse/KOD-4330-2024
dc.authorwosidBouali, Wiem/JGC-9825-2023
dc.contributor.authorYildir, Merve Hatun
dc.contributor.authorGenc, Asena Ayse
dc.contributor.authorErk, Nevin
dc.contributor.authorBouali, Wiem
dc.contributor.authorBugday, Nesrin
dc.contributor.authorYasar, Sedat
dc.contributor.authorDuygulu, Ozgur
dc.date.accessioned2024-08-04T20:55:54Z
dc.date.available2024-08-04T20:55:54Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe successful fabrication is reported of highly crystalline Co nanoparticles interconnected with zeolitic imidazolate framework (ZIF-12) -based amorphous porous carbon using the molten-salt-assisted approach utilizing NaCl. Single crystal diffractometers (XRD), and X-ray photoelectron spectroscopy (XPS) analyses confirm the codoped amorphous carbon structure. Crystallite size was calculated by Scherrer (34 nm) and Williamson-Hall models (42 nm). The magnetic properties of NPCS (N-doped porous carbon sheet) were studied using a vibrating sample magnetometer (VSM). The NPCS has a magnetic saturation (Ms) value of 1.85 emu/g. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses show that Co/Co3O4 nanoparticles are homogeneously distributed in the carbon matrix. While a low melting point eutectic salt acts as an ionic liquid solvent, ZIF-12, at high temperature, leading cobalt nanoparticles with a trace amount of Co3O4 interconnected by conductive amorphous carbon. In addition, the surface area (89.04 m2/g) and pore architectures of amorphous carbon embedded with Co nanoparticles are created using the molten salt approach. Thanks to this inexpensive and effective method, the optimal composite porous carbon structures were obtained with the strategy using NaCl salt and showed distinct electrochemical performance on electrochemical methodology revealing the analytical profile of Erdatifinib (ERD) as a sensor modifier. The linear response spanned from 0.01 to 7.38 mu M, featuring a limit of detection (LOD) of 3.36 nM and a limit of quantification (LOQ) of 11.2 nM. The developed sensor was examined in terms of selectivity, repeatability, and reproducibility. The fabricated electrode was utilized for the quantification of Erdafitinib in urine samples and pharmaceutical dosage forms. This research provides a fresh outlook on the advancements in electrochemical sensor technology concerning the development and detection of anticancer drugs within the realms of medicine and pharmacology.en_US
dc.description.sponsorshipAnkara University [TDK-2023-3036/TDK-2023-3039]; Scientific and Technological Research Council of Turkiye (TUBITAK); Inonu University [FYL-2023-3311]en_US
dc.description.sponsorshipThe authors expressed their gratitude to the Researchers who supported the Ankara University Scientific Research Project numbered TDK-2023-3036/TDK-2023-3039 and the Inonu University Scientific Research Project numbered FYL-2023-3311. This article was prepared within the scope of Merve Hatun Y & imath;ld & imath;r's doctoral thesis.Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK).en_US
dc.identifier.doi10.1007/s00604-024-06318-z
dc.identifier.issn0026-3672
dc.identifier.issn1436-5073
dc.identifier.issue4en_US
dc.identifier.pmid38536529en_US
dc.identifier.scopus2-s2.0-85188957431en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00604-024-06318-z
dc.identifier.urihttps://hdl.handle.net/11616/101907
dc.identifier.volume191en_US
dc.identifier.wosWOS:001195060200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofMicrochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErdafitiniben_US
dc.subjectElectrochemical sensoren_US
dc.subjectModified electrodeen_US
dc.subjectMolten saltsen_US
dc.subjectPorous carbonen_US
dc.subjectVoltammetryen_US
dc.titlePioneering electrochemical detection unveils erdafitinib: a breakthrough in anticancer agent determinationen_US
dc.typeArticleen_US

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