Determination of the pericardial to serum myoglobin ratio for the early diagnosis of perioperative myocardial infarction after coronary artery bypass grafting

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dc.contributor.authorCihan, HB
dc.contributor.authorGulcan, O
dc.contributor.authorHazar, A
dc.contributor.authorTurkoz, R
dc.contributor.authorOlmez, E
dc.date.accessioned2024-08-04T20:15:11Z
dc.date.available2024-08-04T20:15:11Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPericardial fluid reflect the composition of cardiac interstitium in myocardial ischemia. This study investigated the value of the pericardial and serum myoglobin (MG) measurements for the diagnosis of perioperative myocardial infarction (MI) after coronary artery bypass grafting (CABG). Postoperative arterial and pericardial blood samples were taken in 64 subjects undergoing elective CABG allocated to two groups according to the 12-lead electrocardiogram (ECG) abnormalities observed during the first postoperative 24 It. Group 1=normal and nonspesific ECG abnormalities, and Group 2=perioperative Q-wave MI. The occurrence of perioperative MI was associated with a dramatic increase in both serum and pericardial cardiac troponin I (CTnI) and MG concentrations. Pericardial concentrations were higher than serum concentrations during the first postoperative 24 h in all subject. However, pericardial/serum CTnI ratio in subjects in Group 2 was not statistically different from Group I at the time of admission to the intensive care unit (ICU) and did not significantly change at time intervals. On the other hand, more than two-fold increase in the pericardial/serum MG ratio was determined for all patients who experienced perioperative Q-wave MI with the lowest value as 2.75, whereas only 1 of 59 patients in group 1 had the ratio higher than 2 with the highest value as 2.15 at the time of admission to the ICU. In conclusion, determination of pericardial/serum MG ratio may be a useful tool for the early diagnosis of the perioperative MI after CABG. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2004.03.009
dc.identifier.endpage251en_US
dc.identifier.issn1043-6618
dc.identifier.issue3en_US
dc.identifier.pmid15225666en_US
dc.identifier.scopus2-s2.0-3042644857en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2004.03.009
dc.identifier.urihttps://hdl.handle.net/11616/94217
dc.identifier.volume50en_US
dc.identifier.wosWOS:000223670900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmyoglobinen_US
dc.subjecttroponin Ien_US
dc.subjectperioperative myocardial infarctionen_US
dc.titleDetermination of the pericardial to serum myoglobin ratio for the early diagnosis of perioperative myocardial infarction after coronary artery bypass graftingen_US
dc.typeArticleen_US

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