Endothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flow

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dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridPekdemir, Hasan/0000-0002-4913-5120
dc.authoridCansel, Mehmet/0000-0003-4740-4371
dc.authoridTaşolar, Hakan/0000-0002-1249-7240
dc.authoridEyyupkoca, Ferhat/0000-0003-2630-3619
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidPekdemir, Hasan/ABI-6096-2020
dc.authorwosidCansel, Mehmet/ABI-6324-2020
dc.authorwosidTaşolar, Hakan/ABG-4466-2020
dc.authorwosidEyyupkoca, Ferhat/AAE-9244-2022
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.contributor.authorTasolar, Hakan
dc.contributor.authorEyyupkoca, Ferhat
dc.contributor.authorAkturk, Erdal
dc.contributor.authorKarakus, Yasin
dc.contributor.authorCansel, Mehmet
dc.contributor.authorYagmur, Julide
dc.contributor.authorOzyalin, Fatma
dc.date.accessioned2024-08-04T20:37:57Z
dc.date.available2024-08-04T20:37:57Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Endothelial dysfunction plays a key role in the aetiopathogenesis of slow coronary flow (SCF) even if there is no obstructive epicardial lesion. Reduced plasma levels of endothelial nitric oxide synthase (eNOS) are an important indicator of endothelial dysfunction. We aimed to determine plasma levels of eNOS and their relationship with exercise in patients with SCF. Methods: Twenty-two patients with SCF in at least one coronary artery and 17 healthy individuals were included in this study. The TIMI frame count method was used to determine SCF. Plasma levels of eNOS before and after effort were determined in the patient and control groups. Results: Basal eNOS levels in the patient group were lower than in the control group (p = 0.040), and plasma eNOS levels after exercise decreased more significantly in the patient group compared to the control group (p = 0.002). Median decreases of eNOS in response to exercise were higher in the SCF group than in the control group (p < 0.001), and the decrease observed in the control group was not statistically significant (p = 0.35). There were significantly negative correlations between TIMI frame count and plasma levels of eNOS at baseline and after exercise (r = -0.51, p = 0.015, r = -0.58, p = 0.005, respectively). Moreover, there was also a positive correlation between the rate-pressure product and plasma levels of eNOS after exercise in patients with SCF (r = 0.494, p = 0.019). Conclusion: Our findings indicate an important pathophysiological relationship between the severity of SCF in which endothelial dysfunction plays a role in its pathogenesis and the level of circulating plasma levels of eNOS.en_US
dc.identifier.doi10.5830/CVJA-2013-072
dc.identifier.endpage359en_US
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue9-10en_US
dc.identifier.pmid24337211en_US
dc.identifier.scopus2-s2.0-84889239289en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.5830/CVJA-2013-072
dc.identifier.urihttps://hdl.handle.net/11616/96293
dc.identifier.volume24en_US
dc.identifier.wosWOS:000337256000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinics Cardive Publ Pty Ltden_US
dc.relation.ispartofCardiovascular Journal of Africaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectendothelial nitric oxide synthaseen_US
dc.subjectslow coronary flowen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectexerciseen_US
dc.subjectrate-pressure producten_US
dc.titleEndothelial nitric oxide synthase levels and their response to exercise in patients with slow coronary flowen_US
dc.typeArticleen_US

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