Multicenter Study on the Clinical Characteristics, Diagnosis, and Treatment Outcomes of Insulinoma: Insights From 15 Medical Centres

Basit Öğe Kaydı
dc.contributor.authorTopsakal, Senay
dc.contributor.authorYaylali, Guezin Fidan
dc.contributor.authorYarar, Zeliha
dc.contributor.authorMerdin, Fatma Avci
dc.contributor.authorKarsli, Seda
dc.contributor.authorCiftci, Sema
dc.contributor.authorErturk, Mehmet Sercan
dc.date.accessioned2026-04-04T13:33:23Z
dc.date.available2026-04-04T13:33:23Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectiveThis study aimed to evaluate the clinical characteristics, diagnostic approaches, and treatment outcomes of insulinoma patients from diverse regions across the country. We conducted a retrospective analysis of medical records from 76 adult patients diagnosed with insulinoma between 2018 and 2023 at 15 medical centres. Data collected included demographics, presenting symptoms, laboratory and imaging results, surgical reports, pathology findings, and clinical follow-up information. DesignMulti-centre retrospective study. MethodsThe study revealed that key factors such as age, BMI, symptom duration, tumour size, and follow-up period were similar across genders. The majority of patients experienced neuroglycopenic symptoms, particularly during fasting. Insulinoma was typically diagnosed either during fasting or spontaneously, with no significant gender differences in glucose and insulin levels during hypoglycemia. However, men exhibited higher C-peptide levels (p < 0.05). Common comorbidities included hypertension, hypothyroidism, and cardiovascular conditions, and some patients had been using antiepileptics or antidepressants before their diagnosis. ResultsPreoperative tumour diagnoses were largely accurate, with endoscopic ultrasound (EUS) being the most effective method. Most tumours were small ( < 2 cm) and located in the pancreas body, with the majority being solitary. Surgical treatments primarily involved enucleation or distal pancreatectomy. Follow-up data indicated high remission rates, with low rates of nonremission and mortality. ConclusionThis study emphasises that early diagnosis and intervention, particularly in patients with a history of neurological or psychiatric issues, postprandial symptoms, or rapid symptom improvement after treatment, can lead to significantly better outcomes.
dc.description.sponsorshipThe authors received no specific funding for this work.
dc.description.sponsorshipThe authors would like to thank the technical staff at all the hospitals included in the study. The authors received no specific funding for this work.
dc.identifier.doi10.1111/cen.15255
dc.identifier.endpage65
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.issue1
dc.identifier.orcid0000-0002-0411-553X
dc.identifier.orcid0000-0002-6493-9194
dc.identifier.pmid40275816
dc.identifier.scopus2-s2.0-105003440333
dc.identifier.scopusqualityQ2
dc.identifier.startpage57
dc.identifier.urihttps://doi.org/10.1111/cen.15255
dc.identifier.urihttps://hdl.handle.net/11616/109111
dc.identifier.volume103
dc.identifier.wosWOS:001476410000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectanthropometric parameters
dc.subjectcomorbidities
dc.subjectinsulinoma
dc.subjectmortality
dc.subjectprognosis
dc.subjecttreatment modalities
dc.subjecttumour behaviour
dc.titleMulticenter Study on the Clinical Characteristics, Diagnosis, and Treatment Outcomes of Insulinoma: Insights From 15 Medical Centres
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu