Effects of Ginkgo biloba on plasma oxidant injury induced by bleomycin in rats

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dc.authoridER OZTAS, YESIM/0000-0002-8638-9744
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidER OZTAS, YESIM/E-9193-2013
dc.contributor.authorErdogan, H
dc.contributor.authorFadillioglu, E
dc.contributor.authorKotuk, M
dc.contributor.authorIraz, M
dc.contributor.authorTasdemir, S
dc.contributor.authorOztas, Y
dc.contributor.authorYildirim, Z
dc.date.accessioned2024-08-04T20:15:18Z
dc.date.available2024-08-04T20:15:18Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBleomycin is an anti-neoplastic agent and its clinical usage is limited by its toxicity, which is mostly induced by oxygen radicals. The aim of this study was to investigate the effect of Ginkgo biloba on plasma indices of oxidants induced by bleomycin in rats. Male Sprague-Dawley rats were divided into five groups: none medicated or 0.9% NaCl injected or only Ginkgo biloba (orally, 100 mg/kg per day for 14 days) or only a single dose of bleomycin (intratracheal, 2.5 U/kg) or Gingko biloba and bleomycin-treated groups. After 14 days, blood was taken before the rats were sacrificed. The plasma was removed and stored at -85 degrees C until the study day. Plasma superoxide dismutase ( SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) enzyme activities with malondialdehyde and nitric oxide ( NO) levels were studied. The levels of malondialdehyde and NO with activity of XO were higher in plasma of bleomycin group than the other groups (P < 0.05). The activities of SOD and GSH-Px were increased in the bleomycin plus Gingko biloba group in comparison with the bleomycin group (P < 0.05). There was a positive correlation between malondialdehyde and NO levels in the bleomycin group (r = 0.859, P < 0.05). There were positive correlations between SOD and GSH-Px activities (r < 0.760, P < 0.05) and between XO activity and malondialdehyde level (r < 0.822, P < 0.05) in the bleomycin plus Gingko biloba group. In conclusion, it was thought that bleomycin induced oxidative stress can be prevented by Gingko biloba treatment via high anti-oxidant enzyme activity together with decreased radical production from XO.en_US
dc.identifier.doi10.1191/0748233706th245oa
dc.identifier.endpage52en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue1en_US
dc.identifier.pmid16572711en_US
dc.identifier.scopus2-s2.0-33644752755en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1191/0748233706th245oa
dc.identifier.urihttps://hdl.handle.net/11616/94295
dc.identifier.volume22en_US
dc.identifier.wosWOS:000236065000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-oxidanten_US
dc.subjectbleomycinen_US
dc.subjectGingko bilobaen_US
dc.subjectnitric oxideen_US
dc.subjectoxidantsen_US
dc.titleEffects of Ginkgo biloba on plasma oxidant injury induced by bleomycin in ratsen_US
dc.typeArticleen_US

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