Defibrotide activity in experimental frostbite injury
dc.authorscopusid | 35579240900 | |
dc.authorscopusid | 56006411800 | |
dc.authorscopusid | 6701914821 | |
dc.authorscopusid | 7006476274 | |
dc.authorscopusid | 7003945496 | |
dc.authorscopusid | 6603804780 | |
dc.contributor.author | Özyazgan I. | |
dc.contributor.author | Tercan M. | |
dc.contributor.author | Bekerecio?lu M. | |
dc.contributor.author | Melli M. | |
dc.contributor.author | Üstün H. | |
dc.contributor.author | Günay G.K. | |
dc.date.accessioned | 2024-08-04T19:59:05Z | |
dc.date.available | 2024-08-04T19:59:05Z | |
dc.date.issued | 1998 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | The pathogenesis of frostbite injury has not been completely elucidated although the available evidence suggests it is an inflammatory reaction following reperfusion injury. Defibrotide given i.p. at 40 mg/kg/day for three days to rabbits, the ears of which were subjected to frostbite, decreased the presence of inflammatory cells (mast cells -76%; neutrophils -40.4%) and increased prostaglandin I2 (PGI2) (as 6-Keto-PGF(1?)) in the involved skin. Thromboxane A2 (TxA2) (as TxB2)was unaffected. These data strengthen the view that an inflammatory process is the underlying cause of frostbite injury and that Defibrotide is active in pathological situations involving an inflammatory process like in frostbite. | en_US |
dc.description.sponsorship | Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET: SBAG-AYD-4 | en_US |
dc.description.sponsorship | Defibrotide was kindly provided by Dr R. Pescador, Crinos, Piazza XX Settembren 2, 22079 Villa Guardia, Como, Italy. This study was supported by a grant from Erciyes University Research Fund and Turkish Scientific and Technical Research Council (SBAG-AYD-4). | en_US |
dc.identifier.doi | 10.1054/bjps.1997.0061 | |
dc.identifier.endpage | 454 | en_US |
dc.identifier.issn | 0007-1226 | |
dc.identifier.issue | 6 | en_US |
dc.identifier.pmid | 9849365 | en_US |
dc.identifier.scopus | 2-s2.0-0032168583 | en_US |
dc.identifier.scopusquality | N/A | en_US |
dc.identifier.startpage | 450 | en_US |
dc.identifier.uri | https://doi.org/10.1054/bjps.1997.0061 | |
dc.identifier.uri | https://hdl.handle.net/11616/90361 | |
dc.identifier.volume | 51 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Churchill Livingstone | en_US |
dc.relation.ispartof | British Journal of Plastic Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 6 oxoprostaglandin F1 alpha | en_US |
dc.subject | defibrotide | en_US |
dc.subject | prostacyclin | en_US |
dc.subject | thromboxane A2 | en_US |
dc.subject | thromboxane B2 | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | article | en_US |
dc.subject | cold injury | en_US |
dc.subject | controlled study | en_US |
dc.subject | female | en_US |
dc.subject | inflammation | en_US |
dc.subject | intraperitoneal drug administration | en_US |
dc.subject | male | en_US |
dc.subject | mast cell | en_US |
dc.subject | neutrophil | en_US |
dc.subject | nonhuman | en_US |
dc.subject | pathogenesis | en_US |
dc.subject | priority journal | en_US |
dc.subject | rabbit | en_US |
dc.subject | reperfusion injury | en_US |
dc.title | Defibrotide activity in experimental frostbite injury | en_US |
dc.type | Article | en_US |