Defibrotide activity in experimental frostbite injury

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dc.authorscopusid35579240900
dc.authorscopusid56006411800
dc.authorscopusid6701914821
dc.authorscopusid7006476274
dc.authorscopusid7003945496
dc.authorscopusid6603804780
dc.contributor.authorÖzyazgan I.
dc.contributor.authorTercan M.
dc.contributor.authorBekerecio?lu M.
dc.contributor.authorMelli M.
dc.contributor.authorÜstün H.
dc.contributor.authorGünay G.K.
dc.date.accessioned2024-08-04T19:59:05Z
dc.date.available2024-08-04T19:59:05Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe pathogenesis of frostbite injury has not been completely elucidated although the available evidence suggests it is an inflammatory reaction following reperfusion injury. Defibrotide given i.p. at 40 mg/kg/day for three days to rabbits, the ears of which were subjected to frostbite, decreased the presence of inflammatory cells (mast cells -76%; neutrophils -40.4%) and increased prostaglandin I2 (PGI2) (as 6-Keto-PGF(1?)) in the involved skin. Thromboxane A2 (TxA2) (as TxB2)was unaffected. These data strengthen the view that an inflammatory process is the underlying cause of frostbite injury and that Defibrotide is active in pathological situations involving an inflammatory process like in frostbite.en_US
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas, CONICET: SBAG-AYD-4en_US
dc.description.sponsorshipDefibrotide was kindly provided by Dr R. Pescador, Crinos, Piazza XX Settembren 2, 22079 Villa Guardia, Como, Italy. This study was supported by a grant from Erciyes University Research Fund and Turkish Scientific and Technical Research Council (SBAG-AYD-4).en_US
dc.identifier.doi10.1054/bjps.1997.0061
dc.identifier.endpage454en_US
dc.identifier.issn0007-1226
dc.identifier.issue6en_US
dc.identifier.pmid9849365en_US
dc.identifier.scopus2-s2.0-0032168583en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage450en_US
dc.identifier.urihttps://doi.org/10.1054/bjps.1997.0061
dc.identifier.urihttps://hdl.handle.net/11616/90361
dc.identifier.volume51en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofBritish Journal of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject6 oxoprostaglandin F1 alphaen_US
dc.subjectdefibrotideen_US
dc.subjectprostacyclinen_US
dc.subjectthromboxane A2en_US
dc.subjectthromboxane B2en_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectcold injuryen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjectinflammationen_US
dc.subjectintraperitoneal drug administrationen_US
dc.subjectmaleen_US
dc.subjectmast cellen_US
dc.subjectneutrophilen_US
dc.subjectnonhumanen_US
dc.subjectpathogenesisen_US
dc.subjectpriority journalen_US
dc.subjectrabbiten_US
dc.subjectreperfusion injuryen_US
dc.titleDefibrotide activity in experimental frostbite injuryen_US
dc.typeArticleen_US

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