Effects of captopril on ischaemia-reperfusion-induced arrhythmias in an in vivo rat model

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorOlmez, E
dc.contributor.authorBirincioglu, M
dc.contributor.authorAksoy, T
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:11:50Z
dc.date.available2024-08-04T20:11:50Z
dc.date.issued1995
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe antiarrhythmic effects of captopril, an angiotensin converting enzyme (ACE) inhibitor, were investigated in an in vivo rat model of coronary artery ligation. Captopril (0.3-3 mg kg(-1)) or saline were administered by intravenously 10 min before coronary ischaemia. The left main coronary artery was then occluded for 7 min, followed by 7 min of reperfusion. Captopril caused a marked decrease in mean arterial blood pressure which was transient at 0.3 and 1 mg kg(-1), and at doses of 1 and 3 mg kg(-1), it produced marked bradycardia. The incidence of ventricular tachycardia (VT) on ischaemia was significantly reduced the captopril at a dose of 3 mg kg(-1) only and on reperfusion at doses of 1 and 3 mg kg(-1). At the same doses, captopril significantly reduced the mean duration of ventricular fibrillation (VF) on reperfusion. The incidence of mortality resulting from reperfusion-induced irreversible VF in the control group decreased from 42.9% to 14.3% (NS), 21.4% (NS) and 7.7% (P<0.05) in captopril at 0.3, 1 and 3 mg kg(-1), respectively. Our results indicate that captopril appears to limit the arrhythmias following reperfusion and this may be due in part to the antiischemic effect associated with bradycardia and vasodepression. (C) 1995 The Italian Pharmacological Societyen_US
dc.identifier.doi10.1016/S1043-6618(95)80006-9
dc.identifier.endpage41en_US
dc.identifier.issn1043-6618
dc.identifier.issue1-2en_US
dc.identifier.pmid8668645en_US
dc.identifier.scopus2-s2.0-0029559795en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.1016/S1043-6618(95)80006-9
dc.identifier.urihttps://hdl.handle.net/11616/93019
dc.identifier.volume32en_US
dc.identifier.wosWOS:A1995TM13800005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectACE inhibitionen_US
dc.subjectreperfusion arrhythmiasen_US
dc.subjectrat hearten_US
dc.titleEffects of captopril on ischaemia-reperfusion-induced arrhythmias in an in vivo rat modelen_US
dc.typeArticleen_US

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