Dose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult rats

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dc.authoridMiman, Murat Cem/0000-0002-2139-9239
dc.authoridOZTURAN, ORHAN/0000-0002-6129-8627
dc.authorwosidMiman, Murat Cem/AAZ-4873-2020
dc.authorwosidOZTURAN, ORHAN/E-9610-2012
dc.authorwosidOZTURAN, ORHAN/B-4984-2015
dc.contributor.authorErdem, T
dc.contributor.authorOzturan, O
dc.contributor.authorIraz, M
dc.contributor.authorMiman, MC
dc.contributor.authorOlmez, E
dc.date.accessioned2024-08-04T20:14:44Z
dc.date.available2024-08-04T20:14:44Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this animal study was to reveal the dose-dependent effects of melatonin on aminoglycoside ototoxicity by utilizing distortion product otoacoustic emissions (DPOAEs). Forty-four adult ( aged 12 months) rats were divided into five groups. Rats of the control group ( group C) were injected with vehicle, while the melatonin group ( group M) received melatonin ( 4 mg/kg per day); there were four rats in each of these groups. The study groups consisted of 12 rats per group, and they were treated as follows: 600 mg/kg per day amikacin ( group A), amikacin plus a low dose (0.4 mg/kg per day) melatonin ( group AML) and amikacin plus high dose ( 4 mg/kg per day) melatonin ( group AMH) for 14 days. During the serial measurements on days 0, 5, 10 and 15, the DPOAE results of groups C, M and AML were not significantly changed. Amikacin ototoxicity findings for input/output (I/O) functions were detected on the 3rd measurement of the study in group A. High-dose melatonin clearly enhanced and accelerated amikacin-induced ototoxicity. The DP-gram amplitudes and I/O amplitudes were reduced, and I/O thresholds were increased in group AMH. Group AMH was the group that was affected the most and earliest by amikacin. Our study results showed that while low-dose melatonin protected the inner ear from ototoxicity, high dose melatonin facilitated amikacin-induced ototoxicity, possibly via the vasodilatory effect, leading to an increased accumulation of amikacin in the inner ear. Probably, the protective effect of the melatonin at a dose of 0.4 mg/kg per day is related to its antioxidant properties. Apparently, the vasodilatory effect of melatonin seems to be more prominent than its antioxidant effect in high doses.en_US
dc.identifier.doi10.1007/s00405-004-0793-1
dc.identifier.endpage321en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue4en_US
dc.identifier.pmid15170574en_US
dc.identifier.scopus2-s2.0-18744393398en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-004-0793-1
dc.identifier.urihttps://hdl.handle.net/11616/93940
dc.identifier.volume262en_US
dc.identifier.wosWOS:000228638300014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamikacinen_US
dc.subjectdistortion product otoacoustic emissionen_US
dc.subjectmelatoninen_US
dc.subjectototoxicityen_US
dc.subjectpreventionen_US
dc.subjectraten_US
dc.titleDose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult ratsen_US
dc.typeArticleen_US

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