Spirometric predictors for the exclusion of severe hypoxemia in chronic obstructive pulmonary disease

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dc.authorscopusid6603204670
dc.authorscopusid6701614367
dc.contributor.authorGunen H.
dc.contributor.authorKosar F.
dc.date.accessioned2024-08-04T20:00:50Z
dc.date.available2024-08-04T20:00:50Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Controversy has existed over the need for routine arterial blood gas (ABG) analysis in patients with chronic obstructive pulmonary disease (COPD). Some authors recommended it in all patients with COPD, but others find it unnecessary if the forced expiratory volume in 1 s (FEV1) is 50% of predicted or greater. Objectives: To clarify this controversy, and to investigate correlations between severe hypoxemia and multiple spirometric parameters in patients with COPD with FEV1 50% of predicted or greater. Patients and methods: In 103 consecutive patients with COPD with FEV1 50% of predicted or greater, and without any other cardiopulmonary disorder, the incidence of severe hypoxemia (partial pressure of arterial oxygen less than 60 mmHg) was established by ABG analysis. Positive and negative predictive values (PPVs and NPVs, respectively) for severe hypoxemia for multiple spirometric parameters (FEV1,FEV1/forced vital capacity [FVC], peak expiratory flow [PEF], maximal midexpiratory flow rate [FEF25-75]) were evaluated in a stepwise manner. Results: Twenty-two patients (21%) were found to be severely hypoxemic. In the severely hypoxemic group, the mean values for FEV1, FEV1/FVC, PEF and FEF25-75 were 59.0±8.19%, 53.6±11.3, 50.6±9.3 and 34.4±14.2% of predicted, respectively. The mean values for the same parameters in the other patients were 58.0±4.6%, 52.7±7.8, 51.5±7.5 and 39.1±7.7% of predicted, respectively. Comparing these parameters between the two groups, only the difference in FEF25-75 was statistically significant (P<0.01). Valid PPVs and NPVs could not be established for any of the parameters at any level, except for the NPV for FEF25-75 50% of predicted or greater, which was 92%. This threshold value resulted in a false negative finding in less than 5% of the patients with hypoxemia. Conclusions: The results of the present study showed that one in five patients with COPD with FEV1 50% of predicted or greater was severely hypoxemic. In such patients, hypoxemia may be excluded, and ABG analysis may not be needed when the FEF25-75 is also 50% of predicted or greater. The FEV1, FEV1/FVC and PEF parameters failed to predict or exclude severe hypoxemia.en_US
dc.identifier.doi10.1155/2001/701808
dc.identifier.endpage249en_US
dc.identifier.issn1198-2241
dc.identifier.issue4en_US
dc.identifier.pmid11521140en_US
dc.identifier.scopus2-s2.0-0034834061en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://doi.org/10.1155/2001/701808
dc.identifier.urihttps://hdl.handle.net/11616/91037
dc.identifier.volume8en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofCanadian Respiratory Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectHypoxemiaen_US
dc.subjectSpirometryen_US
dc.titleSpirometric predictors for the exclusion of severe hypoxemia in chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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