Clinical, neuroimaging and developmental outcomes of West syndrome

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dc.authorscopusid58978109900
dc.authorscopusid7403011247
dc.authorscopusid58299067500
dc.contributor.authorKarataş K.
dc.contributor.authorTan H.
dc.contributor.authorBaysal Ş.G.
dc.date.accessioned2024-08-04T20:03:38Z
dc.date.available2024-08-04T20:03:38Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. West syndrome is characterized by a hipsarrhytmia pattern on electroencephalography, spasm type seizures, and psychomotor regression triad. In this study, we aimed to document demographic characteristics, clinical and laboratory findings, treatment responses, neurodevelopmental outcomes, and risk factors developed during long-term follow-up with the diagnosis of West syndrome. Materials and methods. The study included patients who were diagnosed with West syndrome between July 2011 and December 2012 in the Department of Pediatric Neurology of Atatürk University. The following data were collected from each patient’s history. Systemic and neurological examinations, cerebral imaging, and electroencephalography were reviewed. Biochemical tests were performed from laboratory tests. The development of each child was assessed using the Denver 2 developmental screening test, the Ankara Developmental Screening Inventory test. Results. The ratio of male/female of our patients was found 2,28/1 and the mean age of the referral was 8.62 ± 7.20 months (median: 8.0). 59 (85.51 %) of the patients were in the symptomatic group and 10 (14.49 %) were in the idiopathic group. The most common factors in the symptomatic group were anomalies of the congenital central nervous system (45.7 %) and hypoxic-ischemic encephalopathy (28.8 %). There was a significant difference between the idiopathic and symptomatic groups in terms of relapse rates, radiological findings, and prognosis rates (p: 0.035/p < 0.001/p < 0.001). Relapse was detected in 43,5 % of the patients. While 83 % of patients treated with adrenocorticotropic hormone, treatment was responded to, 17 % had resistant seizures. There was no statistically significant difference between the treatment responses with adrenocorticotropic hormone and other treatments (p = 0.093). 46 of 55 children (83.6 %) were found to be a developmental delay. Conclusions. Early diagnosis and treatment, the provision of appropriate and convenient treatment in the West syndrome can make a positive contribution to prognosis according to etiology. © Publisher Zaslavsky O.Yu., 2021.en_US
dc.description.sponsorship16.04.2013en_US
dc.description.sponsorshipNo financial support was received from any institution or person for our study. The study was approved by the Ethics Committee of the Faculty of Medicine of Atat\u00FCrk University (date: 16.04.2013, \u2116 7).en_US
dc.identifier.doi10.22141/2224-0713.17.3.2021.231566
dc.identifier.endpage11en_US
dc.identifier.issn2224-0713
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85189908574en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage5en_US
dc.identifier.urihttps://doi.org/10.22141/2224-0713.17.3.2021.231566
dc.identifier.urihttps://hdl.handle.net/11616/91967
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherZaslavsky Publishing Houseen_US
dc.relation.ispartofInternational Neurological Journal (Ukraine)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdevelopmental delayen_US
dc.subjectepilepsyen_US
dc.subjectinfantile spasmsen_US
dc.subjectWest syndromeen_US
dc.titleClinical, neuroimaging and developmental outcomes of West syndromeen_US
dc.typeArticleen_US

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