Evaluation of reproductive toxicity in male rats treated with novel synthesized ruthenium(II) and gold(I)-NHC complexes

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.contributor.authorCiftci, Osman
dc.contributor.authorBeytur, Ali
dc.contributor.authorVardi, Nigar
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:35:41Z
dc.date.available2024-08-04T20:35:41Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to determine the reproductive toxicity in rat induced by ruthenium(II)-NHC (Ru-II) and gold(I)-NHC (Au-I) complexes that have anticarcinogenic effects. For this purpose, 35 Sprague-Dawley rats were randomly divided into 5 equal groups. In control group, rats treated with saline, Ru-II, and Au-I complexes were intraperitoneally given high (10 mg/kg) and low (5 mg/kg) doses to rats via a one-time administration. The animals were sacrificed, and testis tissues were taken on Day 10 of the drug administration for the determination of the biochemical, histopathological, spermatological, and hormonal parameters. It was determined that treatment group that was subjected to treatment using both Ru-II and Au-I complexes significantly caused oxidative, histopathological, spermatological, and hormonal damage compared to control group. However, the sexual and accessory organ weight did not significantly change when compared to control. In addition, it was shown that Au-I treatment generally caused more adverse effects than Ru-II treatment in a dose-dependent manner. In conclusion, when these synthesized compounds are used for the treatment of cancer, they could cause toxic effects on male reproductive system and lead to infertility. However, RuII complex is a more preferable option in cancer treatment, particularly in terms of user safety.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of the Turkish Republic) [109T540]; TUBITAKen_US
dc.description.sponsorshipWe acknowledge the support of TUBITAK (Scientific and Technical Research Council of the Turkish Republic) under Grant 109T540. We thank TUBITAK for their financial support to our project. The authors declared no conflict of interest.en_US
dc.identifier.doi10.3109/03639045.2011.589853
dc.identifier.endpage46en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue1en_US
dc.identifier.pmid21870927en_US
dc.identifier.scopus2-s2.0-82455171799en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.3109/03639045.2011.589853
dc.identifier.urihttps://hdl.handle.net/11616/95498
dc.identifier.volume38en_US
dc.identifier.wosWOS:000297470800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRuthenium(II)en_US
dc.subjectgold(I)en_US
dc.subjectreproductive toxicityen_US
dc.subjecttestis tissueen_US
dc.subjectNHC complexesen_US
dc.titleEvaluation of reproductive toxicity in male rats treated with novel synthesized ruthenium(II) and gold(I)-NHC complexesen_US
dc.typeArticleen_US

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