Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications

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dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidSaraç, Kaya/ABI-1091-2020
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.contributor.authorAlkan, A
dc.contributor.authorKutlu, R
dc.contributor.authorKocak, G
dc.contributor.authorSigirci, A
dc.contributor.authorEmul, M
dc.contributor.authorDogan, S
dc.contributor.authorAslan, M
dc.date.accessioned2024-08-04T20:13:40Z
dc.date.available2024-08-04T20:13:40Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To investigate whether there are metabolite changes in basal ganglia of children with complete healing of rheumatic fever (RF), history of Syndenham chorea (SC) and obsessive compulsive-tic disorder (OCTD) developed after RF when compared with healthy controls and each other. Material and methods: A total of 49 children with history of RF and 31 healthy controls were included into the study. All patients and control group underwent a detailed neuropsychiatric evaluation. Children with the history of RF were classified into-three groups as; group 1: with history of RF without neuropsychiatric complications (NCRF), group 2: only with history of SC (HSC), group 3: with HSC and OCTD (OCTD). After MR imaging, single voxel MR spectroscopy was performed in all subjects. Voxels (15 x 15 x 15 mm) were placed in basal ganglia. N-acetyl aspartate (NAA)/creatin (Cr), and choline (Cho)/Cr ratios were calculated. Results: OCTD were detected in 13 children with HSC. NAA/Cr ratio was found to be decreased in these children when compared with NCRF (n:29), HSC without OCTD (n:7) and control groups (n:3 1). No significant difference was found in metabolite ratios of children with HSC without OCTD when compared with NCRF and control groups. There were no significant differences in Cho/Cr ratio between patient and control groups. Conclusion: Although MR imaging findings was normal, MR spectroscopy findings (decreased NAA/Cr ratio) in our study support the neuronal loss in basal ganglia of children with OCTD and could indicate the development of permanent damage. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0720-048X(03)00177-3
dc.identifier.endpage228en_US
dc.identifier.issn0720-048X
dc.identifier.issue3en_US
dc.identifier.pmid14962651en_US
dc.identifier.scopus2-s2.0-1142297609en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage224en_US
dc.identifier.urihttps://doi.org/10.1016/S0720-048X(03)00177-3
dc.identifier.urihttps://hdl.handle.net/11616/93776
dc.identifier.volume49en_US
dc.identifier.wosWOS:000189242500005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrheumatic feveren_US
dc.subjectchoreaen_US
dc.subjectobsessive compulsive disorderen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.titleBrain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complicationsen_US
dc.typeArticleen_US

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