The level of endothelin-1 and nitric oxide in patients with chronic viral hepatitis B and C and correlation with histopathological grading and staging

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dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridBayindir, Yasar/0000-0003-3930-774X
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.authorwosidBayindir, Yasar/T-1523-2017
dc.contributor.authorErsoy, Y
dc.contributor.authorBayraktar, NM
dc.contributor.authorMizrak, B
dc.contributor.authorOzerol, IH
dc.contributor.authorGunal, S
dc.contributor.authorAladag, M
dc.contributor.authorBayindir, Y
dc.date.accessioned2024-08-04T20:15:12Z
dc.date.available2024-08-04T20:15:12Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description14th European Congress of Clinical Microbiology and Infectious Diseases -- MAY 01-04, 2004 -- Prague, CZECH REPUBLICen_US
dc.description.abstractBackground and aim: The aim of this study was to estimate the serum levels of endothelin-1 (ET-1) and nitric oxide (NO) and to analyze the correlation of their levels with histopathological grading and staging of the liver in patients with chronic hepatitis B (CHB) and C (CHC). Methods: Eighty-nine patients who were either HBsAg positive (45 CHB patients, 34 inactive carriers (IQ) or had CHC (10 patients) and 36 healthy volunteers as a control group were included in this study. Fifty patients from the CHB (n = 43) or CHC (n = 7) groups with elevated serum alanine transaminase (ALT) levels underwent a liver biopsy. Histological activity was scored according to Ishak's activity and the fibrotic index. The ET-1 serum concentration was determined with a commercially available ELISA assay kit. Total nitrite was measured by the Griess reaction as an index for NO production. Results: Serum levels of ET-1 and NO were significantly increased in CHB patients (7.67 +/- 4.00 pg/ml and 172.44 +/- 50.30 mu mol/l, respectively) compared with the IC group (3.99 +/- 5.42 pg/ml and 114.68 +/- 32.22 mu mol/l, respectively) and the control group (3.05 +/- 0.65 pg/ml and 58.61 +/- 24.18 mu mol/l, respectively) (p < 0,000 1). The CHC patients also had significantly higher serum levels of ET- 1 (5.92 +/- 4.24 pg/ml) and NO (147.50 +/- 55.84 mu mol/l) compared to the control group (p < 0.0001 and < 0.001, respectively). Linear regression analysis identified that the level of ET- I was an independent variable that correlated significantly with the stage score (r(2) = 0.348, p < 0.0001) in CHB patients but there was no correlation in the CHC group. Conclusion: ET-1 and NO levels were increased in chronic hepatitis and there was a significant correlation between the ET-I level and the stage in CHB patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.hepres.2005.11.005
dc.identifier.endpage116en_US
dc.identifier.issn1386-6346
dc.identifier.issn1872-034X
dc.identifier.issue2en_US
dc.identifier.pmid16413999en_US
dc.identifier.scopus2-s2.0-31344434702en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1016/j.hepres.2005.11.005
dc.identifier.urihttps://hdl.handle.net/11616/94241
dc.identifier.volume34en_US
dc.identifier.wosWOS:000235502800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHepatology Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic hepatitis Ben_US
dc.subjectchronic hepatitis Cen_US
dc.subjectendothelin-1en_US
dc.subjectnitric oxideen_US
dc.subjecthistopathological grading and stagingen_US
dc.subjecthepatic necroinflammationen_US
dc.titleThe level of endothelin-1 and nitric oxide in patients with chronic viral hepatitis B and C and correlation with histopathological grading and stagingen_US
dc.typeConference Objecten_US

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