Does platelet-rich plasma have a favorable effect in the early stages of steroid-associated femoral head osteonecrosis in a rabbit model?

dc.authoridKarakaplan, Mustafa/0000-0001-9035-0319
dc.authorwosidElmali, Nurzat/A-1017-2014
dc.authorwosidKarakaplan, Mustafa/IXN-3318-2023
dc.contributor.authorKarakaplan, Mustafa
dc.contributor.authorGulabi, Deniz
dc.contributor.authorTopgul, Haldun
dc.contributor.authorElmali, Nurzat
dc.date.accessioned2024-08-04T20:43:56Z
dc.date.available2024-08-04T20:43:56Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: This study aims to investigate the effect of platelet-rich plasma (PRP) on femoral head osteonecrosis and compare it with bone marrow injection and core decompression. Materials and methods: A total of 30 healthy, adult, male New Zealand white rabbits (mean weight 2.25 +/- 0.15 kg; range 2.0 to 2.5 kg) were used in the study. To create experimental osteonecrosis in all rabbits, 40 mg/kg methylprednisolone acetate was applied intramuscularly. Rabbits were randomly allocated into three groups with 10 rabbits in each: drilling group, PRP group, and bone marrow group. The non-drilled hips of the drilling group were identified as the control group. Results: Rate of necrotic bone was lower in the PRP group compared to other groups. Highest rate of necrotic bone was detected in the control group. New bone formation rate was higher in the PRP group compared to other groups. Lowest new bone formation rate was determined in the control group. Inflammatory reaction rate was higher in the PRP group compared to other groups. Conclusion: Platelet-rich plasma injection may play a positive role in the treatment of steroid-associated osteonecrosis in a rabbit model.en_US
dc.identifier.doi10.5606/ehc.2017.54402
dc.identifier.endpage113en_US
dc.identifier.issn1305-8282
dc.identifier.issn1309-0313
dc.identifier.issue2en_US
dc.identifier.pmid28760127en_US
dc.identifier.scopus2-s2.0-85026487971en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.5606/ehc.2017.54402
dc.identifier.urihttps://hdl.handle.net/11616/97909
dc.identifier.volume28en_US
dc.identifier.wosWOS:000406744700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofEklem Hastaliklari Ve Cerrahisi-Joint Diseases and Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone marrowen_US
dc.subjectcore decompressionen_US
dc.subjectosteonecrosisen_US
dc.subjectplatelet-rich plasmaen_US
dc.titleDoes platelet-rich plasma have a favorable effect in the early stages of steroid-associated femoral head osteonecrosis in a rabbit model?en_US
dc.typeArticleen_US

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