Thiol peroxidases mediate specific genome wide regulation of gene expression in response to hydrogen peroxide

Basit Öğe Kaydı
dc.contributor.authorFomenko, Dima
dc.contributor.authorKoç, Ahmet
dc.contributor.authorAgisheva, Natalia
dc.contributor.authorMichael, Jacobsen
dc.contributor.authorKaya, Alaattin
dc.contributor.authorMikalai, Malinouski
dc.contributor.authorJulian, Rutherford
dc.contributor.authorSiu, Kam Leung
dc.contributor.authorYan Jin, Dong
dc.contributor.authorDennis, Winge
dc.contributor.authorVadim, Gladyshe
dc.date.accessioned2017-06-10T13:06:28Z
dc.date.available2017-06-10T13:06:28Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.descriptionProceedings of the National Academy of Sciencesen_US
dc.description.abstractHydrogen peroxide is thought to regulate cellular processes by direct oxidation of numerous cellular proteins, whereas antioxidants, most notably thiol peroxidases, are thought to reduce peroxides and inhibit H2O2 response. However, thiol peroxidases have also been implicated in activation of transcription factors and signaling. It remains unclear if these enzymes stimulate or inhibit redox regulation and whether this regulation is widespread or limited to a few cellular components. Herein, we found that Saccharomyces cerevisiae cells lacking all eight thiol peroxidases were viable and withstood redox stresses. They transcriptionally responded to various redox treatments, but were unable to activate and repress gene expression in response to H2O2. Further studies involving redox transcription factors suggested that thiol peroxidases are major regulators of global gene expression in response to H2O2. The data suggest that thiol peroxidases sense and transfer oxidative signals to the signaling proteins and regulate transcription, whereas a direct interaction between H2O2 and other cellular proteins plays a secondary role.en_US
dc.identifier.citationFomenko, D., KOÇ, A., Agisheva, N., Michael, J., Kaya, A., Mikalai, M., … Vadim, G. (2011). Thiol Peroxidases Mediate Specific Genome Wide Regulation Of Gene Expression İn Response To Hydrogen Peroxide. Proceedings Of The National Academy Of Sciences, 108(7), 2729–2734.en_US
dc.identifier.doi10.1073/pnas.1010721108en_US
dc.identifier.endpage2734en_US
dc.identifier.issue7en_US
dc.identifier.startpage2729en_US
dc.identifier.urihttp://www.pnas.org/cgi/doi/10.1073/pnas.1010721108
dc.identifier.urihttps://hdl.handle.net/11616/7078
dc.identifier.volume108en_US
dc.language.isoenen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.ispartofProceedings of the National Academy of Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThiol peroxidases mediate specific genome wide regulation of gene expression in response to hydrogen peroxideen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
872.51 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı Koleksiyonu