Saponin temelli süpramoleküler hidrojel yapılarının sentezi ve karakterizasyonu
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışma kapsamında, özellikle ilaç salım ve yüksek oranda şişme özelliklerine sahip, multifonksiyonel hidrojel yapıları sentezlendi. Hidrojel yapılarındaki temel yapı bileşeni olarak, saponin grupları belirlendi. Ayrıca kitosan, nişasta, ?-selüloz ve ?-siklodekstrin gibi biyouyumlu gruplar, monomer ünitesi olarak kullanıldı. Hidrojellerin yapısal esnekliği poli(etilen glikol) (PEG) üniteleri kullanarak sağlandı. Bu sayede ilaç salım sistemi olarak kullanılabilecek özelliklere sahip multifonksiyonel saponin temelli hidrojeller elde edildi. Bu yapıların sentezi için öncelikle PEG yapısı epiklorhidrin ile diglisidin eter yapılarına dönüştürüldü. Daha sonra elde edilen diglisidin eter yapıları kullanılarak saponin ve biyouyumlu monomer varlığında polimerizasyonlar gerçekleştirildi. Çalışma neticesinde polieter yapılı çok dallı hidrojel yapıları elde edildi. Hidrojel yapıları temel olarak iki grup dahilinde sentezlendi. Birinci grup sentezlerde epoksi modifiye PEG yapısı, farklı oranlardaki poliol monomerleri varlığında polimerleştirildi. Poliol olarak saponin, kitosan, nişasta, selüloz ve ?-siklodekstrin kullanılarak dört grupta 12 adet farklı hidrojel yapısı elde edildi. İkinci grup sentezlerde ise saponin ve epoksi modifiye PEG yapısından elde edilen hidrojel sistemine 4?-kloro-2,2?:6?,2??-terpiridin yapısı eklenerek metal-ligand etkileşimi ile terpiridin fonksiyonel hidrojel yapıları elde edildi. Çalışma kapsamında hazırlanan hidrojel yapısları, öncelikle Fouriyer transform infrared spektsroskopisi (FTIR) ve elementel analiz ile karekterize edildi. Yüzey ve morfolojik özellikleri, taramalı elektron mikroskobu (SEM) ve optik mikroskop ile incelendi. Termal özellikleri ise termogravimetrik analiz kullanılarak belirlendi. Elde edilen hidrojel yapılarına tetrasiklin yüklemesi yapılarak ilaç salım özellikleri incelendi. Sonuç olarak hidrojel yapıların, ilk 30. dakikadan itibaren belirli düzeyde ilaç salımı yaptığı ve 30. saate kadar düzenli olarak ilaç salımı yapmaya devam ettiği görüldü.
In this study, multifunctional hydrogel structures with drug release and high swelling properties were synthesized. Saponin groups were determined as the basic structural component in the hydrogel structures. In addition, biocompatible groups such as chitosan, starch, ?-cellulose and ?-cyclodextrin were used as monomer units. The structural flexibility of the hydrogels was provided by using poly(ethylene glycol) (PEG) units. In this way, multifunctional saponin-based hydrogels with properties that can be used as drug delivery systems were obtained. For the synthesis of these structures, firstly the PEG structure was converted to diglycidin ether structures with epichlorohydrin. Then, polymerizations were carried out in the presence of saponin and biocompatible monomer using the obtained diglycidin ether structures. As a result of the study, highly branched hydrogel structures with polyether structure were obtained. Hydrogel structures were basically synthesized in two groups. In the first group syntheses, the epoxy modified PEG structure was polymerized in the presence of polyol monomers at different ratios. In addition to, 12 different hydrogel structures were obtained in four groups using saponin, chitosan, starch, cellulose and ?-cyclodextrin as polyol. In the second group of syntheses, 4?-chloro-2,2?:6?,2??-terpyridine structure was added to the hydrogel system obtained from saponin and epoxy modified PEG structure and terpyridine functional hydrogel structures were obtained with metal-ligand interaction. The hydrogel structures prepared within the scope of the study were first characterized by Fourier transform infrared spectroscopy (FTIR) and elemental analysis. Their surface and morphological properties were examined by scanning electron microscope (SEM) and optical microscope. Thermal properties were determined by thermogravimetric analysis. Tetracycline was loaded into the obtained hydrogel structures and drug release properties were examined. As a result, it was observed that the hydrogel structures released a certain level of drug starting from the first 30 minutes and continued to release the drug regularly until the 30th hour.
In this study, multifunctional hydrogel structures with drug release and high swelling properties were synthesized. Saponin groups were determined as the basic structural component in the hydrogel structures. In addition, biocompatible groups such as chitosan, starch, ?-cellulose and ?-cyclodextrin were used as monomer units. The structural flexibility of the hydrogels was provided by using poly(ethylene glycol) (PEG) units. In this way, multifunctional saponin-based hydrogels with properties that can be used as drug delivery systems were obtained. For the synthesis of these structures, firstly the PEG structure was converted to diglycidin ether structures with epichlorohydrin. Then, polymerizations were carried out in the presence of saponin and biocompatible monomer using the obtained diglycidin ether structures. As a result of the study, highly branched hydrogel structures with polyether structure were obtained. Hydrogel structures were basically synthesized in two groups. In the first group syntheses, the epoxy modified PEG structure was polymerized in the presence of polyol monomers at different ratios. In addition to, 12 different hydrogel structures were obtained in four groups using saponin, chitosan, starch, cellulose and ?-cyclodextrin as polyol. In the second group of syntheses, 4?-chloro-2,2?:6?,2??-terpyridine structure was added to the hydrogel system obtained from saponin and epoxy modified PEG structure and terpyridine functional hydrogel structures were obtained with metal-ligand interaction. The hydrogel structures prepared within the scope of the study were first characterized by Fourier transform infrared spectroscopy (FTIR) and elemental analysis. Their surface and morphological properties were examined by scanning electron microscope (SEM) and optical microscope. Thermal properties were determined by thermogravimetric analysis. Tetracycline was loaded into the obtained hydrogel structures and drug release properties were examined. As a result, it was observed that the hydrogel structures released a certain level of drug starting from the first 30 minutes and continued to release the drug regularly until the 30th hour.
Açıklama
Anahtar Kelimeler
Kimya, Chemistry
