Hemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia in coronary artery bypass surgery

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dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.contributor.authorBut, AK
dc.contributor.authorDurmus, M
dc.contributor.authorToprak, HI
dc.contributor.authorOzturk, E
dc.contributor.authorDemirbilek, S
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:15:02Z
dc.date.available2024-08-04T20:15:02Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to compare the hemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia during coronary artery bypass surgery. Design: Prospective study. Setting: University hospital. Participants: Sixty patients undergoing elective coronary artery bypass grafting surgery with ejection fraction more than 45%. Interventions: Anesthesia was induced with etomidate, 0.2 mg/kg, and fentanyl, 5 mu g/kg, in group D (n = 30) and with midazolam, 0.1 to 0.3 mg/kg, and fentanyl, 5 mu g/kg, in group M (n = 30). Anesthesia was maintained with desflurane, 2% to 6%, and fentanyl, 15 to 25 mu g/kg, in group D and midazolam infusion, 0.1 to 0.5 mg/kg/h, and fentanyl, 15 to 25 mu g/kg, in group M. Measurements and Main Results: Hemodynamic monitoring included a 5-lead electrocardiogram, a radial artery catheter, and a pulmonary artery catheter. Data were obtained before induction of anesthesia (t(0)), after induction of anesthesia (t(1)), after intubation (t(2)), after surgical incision (t(3)), after sternotomy (t(4)), before cardiopulmonary bypass (t(5)), after protamine infusion (t(6)), and at the end of the surgery (t(7)). Blood samples were obtained to measure total bilirubin, aspartate aminotransferase, gamma glutamyl transferase, lactate dehydrogenase, alkaline phosphatase, creatinine, and blood urea nitrogen just before induction of anesthesia and at the first, fourth, and 14th days postoperatively. Conclusions: Intraoperative hemodynamic responses were similar in both groups, and transient hepatic and renal dysfunctions were observed in the postoperative period in both groups. The extubation and intensive care unit discharge times were found to be shorter in the desflurane-fentanyl group. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1053/j.jvca.2004.10.009
dc.identifier.endpage602en_US
dc.identifier.issn1053-0770
dc.identifier.issn1532-8422
dc.identifier.issue5en_US
dc.identifier.pmid16202892en_US
dc.identifier.scopus2-s2.0-25844476189en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.1053/j.jvca.2004.10.009
dc.identifier.urihttps://hdl.handle.net/11616/94120
dc.identifier.volume19en_US
dc.identifier.wosWOS:000233054400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Cardiothoracic and Vascular Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcoronary artery bypass graftingen_US
dc.subjectdesiluraneen_US
dc.subjectmidazolamen_US
dc.subjectkidneyen_US
dc.subjectliveren_US
dc.subjectpostoperative effectsen_US
dc.titleHemodynamic, hepatorenal, and postoperative effects of desflurane-fentanyl and midazolam-fentanyl anesthesia in coronary artery bypass surgeryen_US
dc.typeArticleen_US

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