Ashwagandha is protective of impaired motor-coordination in experimental CI/R damage in rats

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dc.contributor.authorTanbek, Kevser
dc.contributor.authorBirdal, Berfin
dc.contributor.authorCanal, Betül Cansu
dc.contributor.authorÇelikli, Dilara
dc.contributor.authorÇetin, Emrullah
dc.contributor.authorCansel, Eyüp İbrahim
dc.contributor.authorBulut, Fatma Nur
dc.date.accessioned2026-04-04T13:14:38Z
dc.date.available2026-04-04T13:14:38Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractAim: Cerebral ischemia (CI) is a condition in which metabolic stress increases when blood flow to a part of the brain is interrupted, resulting in oxygen and glucose deprivation. Later, during the treatment process, the ischemic tisue is reperfused, causing more neurological damage than the ischemic process. For this reason, developing protective practices in individuals at high risk of CI is much more important than developing treatment practices. Ashwagandha (ASW), an extract of the W.somnifera plant, is an agent with antioxidant, anti-inflammatory, antiapoptotic and neuroprotective effects. It has been reported in the literature that ASW is effective against neuropathological damage with different experimental models. In this study, it was aimed to explain the protective effect of ASW against CI/reperfusion damage. Materials and Methods: 30 Spraque Dawley male rats were divided into 3 groups as Sham, CI, ASW+CI (n=10). 60 min CI was created using the intraluminal filament technique and sacrificed at the end of the 24-hour reperfusion period. ASW (200 mg/kg/day) was administered orally for 7 days before CI. Motor coordination was evaluated with rotarot test before and after CI. Infarct area was determined by triphenyltetrazolium chloride (TTC) staining. Kruskal-Wallis test was used to compare the differences between the groups. p<0.05 was considered statistically significant. Results: Neurological evaluations of the experimental groups were scored as ASW+CI (2), CI (3.5) and Sham (0). Infarct areas were calculated as Sham (0), CI (% 45.7) and ASW+CI (% 32.6). Post-ischemia rota-rot test results evaluating motor coordination were measured as Sham (280 sec), CI (15 sec) and ASW+CI (86 sec). Compared with the sham group, the increase in neurological score and ischemic area and the decrease in rota rot time in the CI and ASW+CI groups are statistically significant (p≤0.05). Compared with the ASW+CI group, the decrease in neurological score and ischemic area and the increase in rota rot time are statistically significant (p≤0.05). Conclusion: ASW has protective effects against CI/R injury. 7-day ASW application before ischemia reduced the ischemic area. It reduced neurological damage, regulated motor coordination and maintained the neuronal death/survival balance against CI/R injury.
dc.identifier.doi10.5455/annalsmedres.2024.08.168
dc.identifier.endpage815
dc.identifier.issn2636-7688
dc.identifier.issue10
dc.identifier.startpage809
dc.identifier.trdizinid1275952
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2024.08.168
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1275952
dc.identifier.urihttps://hdl.handle.net/11616/107364
dc.identifier.volume31
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectTamamlayıcı ve Entegre Tıp
dc.subjectNörolojik Bilimler
dc.titleAshwagandha is protective of impaired motor-coordination in experimental CI/R damage in rats
dc.typeArticle

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