Acute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patients

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dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.contributor.authorKartalci, Sukru
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorOzcan, Abdul Cemal
dc.contributor.authorPorgali, Esra
dc.contributor.authorUnal, Suheyla
dc.date.accessioned2024-08-04T20:35:32Z
dc.date.available2024-08-04T20:35:32Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractElectroconvulsive therapy (ECT) is an effective treatment alternative for schizophrenia. Previous studies have already indicated the possible effects of oxidative stress in this disorder. However, there have been no previous studies evaluating the effects of ECT on the oxidative stress in these patients. We therefore aimed to investigate the acute and chronic effects of ECT on serum levels of oxidant and antioxidant molecules in schizophrenia patients (n = 28). The serum MDA and CAT levels of the patients with schizophrenia were higher than that of the controls before ECT (n = 20) but there was no significant difference in the serum NO and GSH levels of the patient groups compared to the controls. We found that the NO levels of the patients were higher than the controls in the group experiencing their first episode but not in the chronic group. There was a significant clinical improvement in the patients in terms of BPRS. SANS and SAPS reduction after the 9th ECT, but not the 1st ECT. Serum MDA levels were significantly reduced compared to the baseline after the 9th ECT session although there was no significant difference after the 1st session. Separate evaluation of the patient groups revealed that the significant MDA decrease following ECT was in the patients experiencing their first episode and not in the chronic group. No significant difference was noted in the serum levels of other oxidant and antioxidant molecules after either the 1st or 9th ECT session. These results suggest that ECT does not produce any negative effect on oxidative stress in patients with schizophrenia. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2011.05.007
dc.identifier.endpage1694en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue7en_US
dc.identifier.pmid21620920en_US
dc.identifier.scopus2-s2.0-79961126642en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1689en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2011.05.007
dc.identifier.urihttps://hdl.handle.net/11616/95396
dc.identifier.volume35en_US
dc.identifier.wosWOS:000294941800023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectroconvulsive therapyen_US
dc.subjectOxidative stressen_US
dc.subjectSchizophreniaen_US
dc.titleAcute and chronic effects of electroconvulsive treatment on oxidative parameters in schizophrenia patientsen_US
dc.typeReview Articleen_US

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