Diffusion-weighted imaging measurements of central smell regions in COVID-19 patients: insular gyrus, corpus amygdala, and thalamus

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.authoridSayar, Merve Sefa/0000-0002-0436-4122;
dc.authorwosidBAYAR MULUK, NURAY/JJE-2906-2023
dc.authorwosidSayar, Merve Sefa/GVS-7640-2022
dc.authorwosidBurulday, Veysel/V-6075-2017
dc.contributor.authorBurulday, V.
dc.contributor.authorMuluk, N. bayar
dc.contributor.authorAkgul, M. H.
dc.contributor.authorSayar, M. S.
dc.date.accessioned2024-08-04T20:53:40Z
dc.date.available2024-08-04T20:53:40Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to investigate central smell centers with cranial magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI) in COVID-19.PATIENTS AND METHODS: This retrospec-tive study evaluated cranial MRI images of 54 adults. The experimental group (Group 1), con-sisting of 27 patients with positive COVID-19 real-time Polymerase Chain Reaction (RT-PCR) assays, was compared to the control group (Group 2), comprising 27 healthy con-trols without COVID-19. The apparent diffu-sion coefficient (ADC) values were measured in the corpus amygdala, thalamus, and insular gyrus in both groups. RESULTS: Thalamus ADC values of the COVID-19 group were significantly lower com-pared to the control group bilaterally. Howev-er, no differences were found in the insular gy-rus and corpus amygdala ADC values between the two groups. Positive correlations were ob-served between the insular gyrus and cor-pus amygdala ADC values and the thalamus ADC values. Insular gyrus ADC values (right) were higher in females. Left insular gyrus and corpus amygdala ADC values were higher in COVID-19 patients with smell loss. Right in-sular gyrus and left corpus amygdala ADC values were lower in COVID-19 patients with lymphopenia.CONCLUSIONS: Diffusion restriction in ol-factory areas can be considered an obvious indicator that the COVID-19 virus affects and damages the immune system at the neuro-nal level. Given the urgency and lethality of the current pandemic, acute onset odor loss should be considered a high suspicion-adhe-sive index for patients with SARS-CoV-2 infec-tion. Therefore, the sense of smell should be considered and evaluated simultaneously with other neurological symptoms. DWI should be widely used as an early imaging method for central nervous system (CNS) infections, espe-cially in relation to COVID-19.en_US
dc.identifier.endpage3207en_US
dc.identifier.issn1128-3602
dc.identifier.issue7en_US
dc.identifier.pmid37070924en_US
dc.identifier.scopus2-s2.0-85152971539en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3201en_US
dc.identifier.urihttps://hdl.handle.net/11616/101300
dc.identifier.volume27en_US
dc.identifier.wosWOS:000982646100026en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectDiffusion-weighted imaging (DWI)en_US
dc.subjectAp-parent diffusion coefficient (ADC)en_US
dc.subjectCranial MRIen_US
dc.subjectCen-tral smell centersen_US
dc.titleDiffusion-weighted imaging measurements of central smell regions in COVID-19 patients: insular gyrus, corpus amygdala, and thalamusen_US
dc.typeArticleen_US

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