Evaluation of biological activities of Barbarea integrifolia and isolation of a new glucosinolate derivated compound

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dc.authoridÇalış, İhsan/0000-0001-5489-3420
dc.authoridŞALVA, EMINE/0000-0002-1159-5850
dc.authoridKaban, Kübra/0000-0001-7311-7187
dc.authoridSENER, SILA OZLEM/0000-0001-7679-7165
dc.authorwosidÇalış, İhsan/CAH-7381-2022
dc.authorwosidSENER, Sila Ozlem/AAT-5338-2020
dc.authorwosidŞALVA, EMINE/CAH-3062-2022
dc.authorwosidKaban, Kübra/JFB-1837-2023
dc.contributor.authorBadem, Merve
dc.contributor.authorSener, Sila Ozlem
dc.contributor.authorKanbolat, Seyda
dc.contributor.authorKorkmaz, Nuriye
dc.contributor.authorYildirmis, Sermet
dc.contributor.authorOzgen, Ufuk
dc.contributor.authorAliyazicioglu, Rezzan
dc.date.accessioned2024-08-04T20:49:29Z
dc.date.available2024-08-04T20:49:29Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study is to determine the potent biological activities and carry out isolation studies on Barbarea integrifolia. The antioxidant capacity of the species was evaluated by total phenolic content, FRAP, CUPRAC, and DPPH radical scavenging activity. Anticancer activity studies were performed by MTT assay in MDA-MB-231, MCF-7, Hep3B, PC-3, A549, HCT116, L-929 cell lines. It was observed that the remaining aqueous fraction has higher total phenolic content while higher activity in the CUPRAC and FRAP assays was displayed for the methanolic extract and chloroform fraction. The extracts showed anticancer activity as compared with vincristine. It was observed that chloroform fraction has the highest anticancer activity on MCF-7 cell line, while ethyl acetate fraction has the highest anticancer activity on Hep-3B and A549 cell lines. Methanolic extract has the highest anticancer activity on HCT116 and MDA-MB-23 cell lines. The isolation studies have been performed using several chromatographic methods. The chemical structures of compounds have been identified by means of H-1 NMR, C-13 NMR, 2D-NMR, and MS. Five major compounds, one steroid (beta-Sitosterol), one phenolic acid (Rosmarinic acid), one flavonol heteroside (kaempferol 7-O-alpha-L-rhamnoside-3-O-beta-D-(2-O-beta-D-glucosyl)-beta-D-glucoside), and two glucosinolates (Gluconasturtiin, Gluconasturtiin choline salt) have been isolated.en_US
dc.description.sponsorshipKaradeniz Technical University Scientific Research Projects Unit [THD-2018-7353]en_US
dc.description.sponsorshipThe study was financially supported by Karadeniz Technical University Scientific Research Projects Unit under the grant THD-2018-7353.en_US
dc.identifier.doi10.1515/znc-2020-0305
dc.identifier.endpage382en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue9-10en_US
dc.identifier.pmid33823106en_US
dc.identifier.scopus2-s2.0-85104481836en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1515/znc-2020-0305
dc.identifier.urihttps://hdl.handle.net/11616/99892
dc.identifier.volume76en_US
dc.identifier.wosWOS:000692699300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanticancer activityen_US
dc.subjectantioxidanten_US
dc.subjectBarbareaen_US
dc.subjectBrassicaceaeen_US
dc.subjectgluconasturtiin choline salten_US
dc.titleEvaluation of biological activities of Barbarea integrifolia and isolation of a new glucosinolate derivated compounden_US
dc.typeArticleen_US

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