Histological and Biochemical Effects of Dexmedetomidine on Liver during an Inflammatory Bowel Disease

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridKAYHAN, BASAK/0000-0003-3508-2563
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidKAYHAN, BASAK/ABH-9314-2020
dc.contributor.authorGul, Mehmet
dc.contributor.authorKayhan, Basak
dc.contributor.authorElbe, Hulya
dc.contributor.authorDogan, Zumrut
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:40:01Z
dc.date.available2024-08-04T20:40:01Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease. Thirty-two BALB/c mice were divided (n = 8) as follows: control; Dex (dexmedetomidine) (30 mu g/kg) for 6 days; TNBS 150 mu L, TNBS_ethanol (50% w/v) intrarectally; TNBS_Dex. The histopathological and ultrastructural changes were evaluated. The levels of malondialdehyde (MDA), activity of antioxidant enzymes (GPx and SOD) were measured in liver tissue. Induction of colitis induced histopathological and ultrastructural changes of damage in liver. Those changes were markedly reduced in the TNBS_Dex group and that reduction was even significant in comparison to the TNBS group. MDA levels were significantly higher in the TNBS group and dexmedetomidine significantly elevated SOD levels in the TNBS_Dex group. These results suggest that the administration of dexmedetomidine reduces the histopathological and ultrastructural damage and increases the defense capacity against oxidative damage on liver in this IBD mice model.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [110S243]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) in short-term R&D Funding Programme (110S243).en_US
dc.identifier.doi10.3109/01913123.2013.829150
dc.identifier.endpage12en_US
dc.identifier.issn0191-3123
dc.identifier.issue1en_US
dc.identifier.pmid24134660en_US
dc.identifier.scopus2-s2.0-84921729896en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.3109/01913123.2013.829150
dc.identifier.urihttps://hdl.handle.net/11616/96663
dc.identifier.volume39en_US
dc.identifier.wosWOS:000348916000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectelectron microscopyen_US
dc.subjectinflammationen_US
dc.subjectinflammatory bowel diseaseen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.titleHistological and Biochemical Effects of Dexmedetomidine on Liver during an Inflammatory Bowel Diseaseen_US
dc.typeArticleen_US

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