Neuroimaging findings in hyperargininemia

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dc.authoridAkinci, Aysehan/0000-0001-7267-9444
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidAkinci, Aysehan/AAC-6847-2021
dc.contributor.authorGungor, Serdal
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorFirat, Ahmet Kemal
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorAlkan, Alpay
dc.date.accessioned2024-08-04T20:30:56Z
dc.date.available2024-08-04T20:30:56Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn hyperarginenemia, there is a defect in argininase enzyme, which is a catalyzer of urea cycle. Though the pathogenesis of neuronal damage in hyperargininemia is not clear, high serum and cerebrospinal fluid arginine levels can be directly related with neuronal damage. In this study, our aim was to assess brain magnetic resonance images and magnetic resonance spectroscopy (MRS) patterns of two siblings with hyperarginenemia. We acquired single voxel MRS from the white matter to show the myelination pattern and to figure out any abnormal peak of metabolite stored due to enzymatic defect. We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3.8 ppm, most likely representing arginine deposition. To the best of our knowledge, this is the first article revealing the brain MRS pattern of hyperargininemia. We reported the clinical and imaging findings of patients and discuss the correlation.en_US
dc.identifier.doi10.1111/j.1552-6569.2007.00217.x
dc.identifier.endpage462en_US
dc.identifier.issn1051-2284
dc.identifier.issue4en_US
dc.identifier.pmid18321250en_US
dc.identifier.scopus2-s2.0-49149109465en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1111/j.1552-6569.2007.00217.x
dc.identifier.urihttps://hdl.handle.net/11616/94615
dc.identifier.volume18en_US
dc.identifier.wosWOS:000259836300020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArginase Deficiencyen_US
dc.subjectCerebral Edemaen_US
dc.subjectSpectroscopyen_US
dc.subjectMetabolismen_US
dc.subjectInductionen_US
dc.subjectGlutamineen_US
dc.titleNeuroimaging findings in hyperargininemiaen_US
dc.typeArticleen_US

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