Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy

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dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridcolak, yusuf ziya/0000-0002-8729-8705
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridErdogan Kayhan, Gulay/0000-0002-2635-9295
dc.authoridKarlıdağ, Rifat/0000-0002-3650-0774
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidcolak, yusuf ziya/ABH-3032-2020
dc.authorwosidkarlıdağ, rıfat/AAB-4255-2021
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidErdogan Kayhan, Gulay/JVZ-0037-2024
dc.contributor.authorKayhan, G. Erdogan
dc.contributor.authorYucel, A.
dc.contributor.authorColak, Y. Z.
dc.contributor.authorOzgul, U.
dc.contributor.authorYologlu, S.
dc.contributor.authorKarlidag, R.
dc.contributor.authorErsoy, M. O.
dc.date.accessioned2024-08-04T20:35:50Z
dc.date.available2024-08-04T20:35:50Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of a ketamine:propofol combination ('ketofol') for electroconvulsive therapy on seizure activity, haemodynamic response and recovery parameters, and to compare with these with the effects of propofol alone. Twenty-four patients underwent a total of 144 electroconvulsive therapy sessions, allocated in this prospective, double-blind, crossover study. Patients were randomly assigned to receive 1 mg/kg ketofol (0.5 mg/kg propofol plus 0.5 mg/kg ketamine) or 1 mg/kg propofol 1% for anaesthesia induction. Seizure duration and quality, haemodynamic data, recovery parameters and side-effects were recorded and analysed between groups. Both motor and electroencephalography seizure durations in the ketofol group (29 +/- 17 and 41 +/- 17 seconds, respectively) were similar to that in the propofol group (28 +/- 13 and 38 +/- 16 seconds, respectively). Postictal suppression index was higher in the ketofol group (89.63 +/- 7.88) than in the propofol group (79.74 +/- 14.6) (P <0.05). In the ketofol group, heart rate after the seizure ended and mean arterial pressures, recorded at 0 and 5 minutes after the seizure ended, were higher than in the propofol group. Time to obeying commands was longer in the ketofol group (P <0.05). There were no untoward psychological reactions following ketofol. Although no superiority to propofol in terms of seizure duration, haemodynamic or recovery parameters was found, the ketofol mixture selected in our study provided better seizure quality than propofol. We conclude that ketofol can be an alternative strategy to enhance the seizure quality and clinical efficiency of electroconvulsive therapy.en_US
dc.identifier.doi10.1177/0310057X1204000214
dc.identifier.endpage310en_US
dc.identifier.issn0310-057X
dc.identifier.issn1448-0271
dc.identifier.issue2en_US
dc.identifier.pmid22417026en_US
dc.identifier.scopus2-s2.0-84858957981en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1177/0310057X1204000214
dc.identifier.urihttps://hdl.handle.net/11616/95601
dc.identifier.volume40en_US
dc.identifier.wosWOS:000301998600014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAustralian Soc Anaesthetistsen_US
dc.relation.ispartofAnaesthesia and Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectketamineen_US
dc.subjectpropofolen_US
dc.subjectelectroconvulsive therapyen_US
dc.titleKetofol (mixture of ketamine and propofol) administration in electroconvulsive therapyen_US
dc.typeArticleen_US

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