Ultrastructural findings and tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression in psoriasis patients before and after oral cyclosporin A therapy

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorGul, Mehmet
dc.contributor.authorSeyhan, Muammer
dc.date.accessioned2024-08-04T20:15:24Z
dc.date.available2024-08-04T20:15:24Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.descriptionMeeting of the Society-for-Ultrastructural-Pathology/Annual Session of the United-States-and-Canadian-Academy-of-Pathology -- FEB, 2005 -- San Antonio, TXen_US
dc.description.abstractElevated levels of proinflammatory cytokines, including tumor necrosis factor-alpha, are found in skin lesions and plasma of patients with psoriasis. Clinical improvement of psoriasis with cyclosporin A treatment is accompanied by downmodulation of proinflammatory epidermal cytokines. In this study to determine the effects of cyclosporin A on the ultrastructural changes and tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression in psoriasis, biopsy specimens before and after cyclosporin A treatment were evaluated ultrastructurally and immunohistochemically. Ten patients were given 3-7.5 mg/kg oral cyclosporin A for 6 months. Before and after treatment full thickness of 4-mm punch biopsies were obtained from patients and from 6 healthy volunteers. Samples were processed for electron microscopic and immunohistochemical evaluation. The treatment was well tolerated with complete clinical improvement. The ultrastructural changes such as reduction of tonofilaments, dilatation of intercellular space, and interruption in lamina densa were recovered by cyclosporin A treatment. The increased staining intensity of tumor necrosis factor-alpha and intercellular adhesion molecule-1 on epidermal keratinocytes and endothelial cells was reduced after cyclosporin A therapy. Cyclosporin A treatment results in total normalization of the electron microscopic picture of psoriasis and its beneficial effect depends on the direct inhibition of tumor necrosis factor-alpha and consequently intercellular adhesion molecule-1.en_US
dc.description.sponsorshipSoc Ultrastructural Pathol,US Canadian Acad Patholen_US
dc.identifier.doi10.1080/01013120500406616
dc.identifier.endpage102en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue1-2en_US
dc.identifier.pmid16517475en_US
dc.identifier.scopus2-s2.0-33645996424en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.1080/01013120500406616
dc.identifier.urihttps://hdl.handle.net/11616/94365
dc.identifier.volume30en_US
dc.identifier.wosWOS:000238155000011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbasement membraneen_US
dc.subjectICAM-1en_US
dc.subjectpsoriasisen_US
dc.subjectTNF-alphaen_US
dc.subjecttransmission electron microscopyen_US
dc.titleUltrastructural findings and tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression in psoriasis patients before and after oral cyclosporin A therapyen_US
dc.typeConference Objecten_US

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