Biomarkers of immune hyperactivation and inflammation are elevated in pregnancies complicated by fetal Trisomy-21

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dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorSinaci, Selcan
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorUnuvar, Songul
dc.contributor.authorCelik, Nesibe Zeyveli
dc.contributor.authorYasar, Seyma
dc.contributor.authorPolat, Busra Berfin
dc.date.accessioned2026-04-04T13:33:32Z
dc.date.available2026-04-04T13:33:32Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective To compare interferon-linked/inflammatory biomarkers (neopterin, indoleamine-2,3-dioxygenase [IDO], and YKL-40) in maternal serum and amniotic fluid between Trisomy-21 and chromosomally normal pregnancies. Methods This prospective case-control study included pregnancies diagnosed with Trisomy-21 and chromosomally normal pregnancies as controls. Neopterin, IDO, and YKL-40 levels in maternal serum and amniotic fluid samples were measured using ELISA. Results Neopterin and YKL-40 levels were significantly higher in amniotic fluid (p < 0.05) and maternal serum (p < 0.05), respectively, in the Trisomy-21 group. Maternal serum IDO showed a trend toward increase in Trisomy-21 pregnancies, while amniotic fluid levels did not differ between groups. All measurements were above assay detection limits. Conclusion Trisomy-21 pregnancies showed elevated AF neopterin and elevated MS YKL-40, while IDO was not significantly different. This pattern is compatible with differences in interferon-linked inflammatory/vascular pathways in Trisomy-21 pregnancies, but does not establish a mechanism. Further studies are needed to validate these findings.
dc.identifier.doi10.1080/14767058.2025.2597589
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue1
dc.identifier.orcid0000-0002-8342-1956
dc.identifier.orcid0000-0003-3118-4036
dc.identifier.orcid0000-0003-1300-3393
dc.identifier.orcid0000-0001-7113-6691
dc.identifier.orcid0000-0001-8454-490X
dc.identifier.orcid0000-0002-8332-7273
dc.identifier.pmid41360609
dc.identifier.scopus2-s2.0-105024146623
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/14767058.2025.2597589
dc.identifier.urihttps://hdl.handle.net/11616/109230
dc.identifier.volume38
dc.identifier.wosWOS:001636114300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectTrisomy-21
dc.subjectneopterin
dc.subjectindoleamine-2,3-dioxygenase
dc.subjectYKL-40
dc.subjectimmune activation
dc.subjectinflammation
dc.titleBiomarkers of immune hyperactivation and inflammation are elevated in pregnancies complicated by fetal Trisomy-21
dc.typeArticle

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