The effects of pentoxifylline and caffeic acid phenethyl ester on TNF-? and lung histopathology in D-galactosamine-induced pulmonary injury in rats

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dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorTaslidere, Elif
dc.contributor.authorVardi, Nigar
dc.contributor.authorYildiz, Azibe
dc.contributor.authorAtes, Burhan
dc.contributor.authorEsrefoglu, Mukaddes
dc.date.accessioned2024-08-04T20:53:34Z
dc.date.available2024-08-04T20:53:34Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to investigate the effects of pentoxifylline [PTX] and caffeic acid phenethyl ester [CAPE] in D-galactosamine [D-GAL]-induced pulmonary injury in rats. The rats were randomly divided into six groups: control, D-GAL, D-GAL+PTX, D-GAL+CAPE, PTX and CAPE. Each group included eight animals. Lung sections from the control, PTX and CAPE groups had a normal histological appearance. The D-GAL group showed histopathological changes in lung tissue, including haemorrhage, oedema, inter-alveolar septal thickening and widespread infiltration of inflammatory lymphocytes and macrophages. Administration of PTX and CAPE significantly reduced histopathological damage scores in the D-GAL+PTX and D-GAL+CAPE groups compared with the D-GAL group. PTX and CAPE treatment also significantly decreased malondialdehyde levels, increased levels of reduced GSH and increased catalase and superoxide dismutase activity in lung tissue samples. These results indicate that the destructive effects of D-GAL-induced inflammation in the rat lung are significantly reduced following administration of PTX and CAPE.en_US
dc.identifier.doi10.1016/j.tice.2023.102085
dc.identifier.issn0040-8166
dc.identifier.pmid37018928en_US
dc.identifier.scopus2-s2.0-85151424128en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2023.102085
dc.identifier.urihttps://hdl.handle.net/11616/101268
dc.identifier.volume82en_US
dc.identifier.wosWOS:000973364700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGalactosamineen_US
dc.subjectPentoxifyllineen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectLungen_US
dc.subjectRaten_US
dc.titleThe effects of pentoxifylline and caffeic acid phenethyl ester on TNF-? and lung histopathology in D-galactosamine-induced pulmonary injury in ratsen_US
dc.typeArticleen_US

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