Synthesis, Characterization, Anticholinesterase, and Antioxidant Properties of Quinoxalin-2(1H)-One Functionalized (Benz)Imidazol-3-Ium Salts as Hybrid Molecules in Drug Discovery

Basit Öğe Kaydı
dc.contributor.authorKaloglu, Nazan
dc.contributor.authorBoga, Mehmet
dc.contributor.authorErcan, Selami
dc.contributor.authorCinar, Ercan
dc.contributor.authorBektasli, Yonca
dc.contributor.authorKaloglu, Murat
dc.date.accessioned2026-04-04T13:37:36Z
dc.date.available2026-04-04T13:37:36Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractIn the present study, biologically active quinoxalin-2(1H)-one and (benz)imidazole scaffolds were successfully integrated into single hybrid molecules. As a result, five new quinoxalin-2(1H)-one-functionalized (benz)imidazol-3-ium salts were synthesized. The structures of these newly designed hybrids, synthesized for the first time, were confirmed through spectroscopic techniques and elemental analysis. The in vitro anticholinesterase activities of the hybrids were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). In addition, their antioxidant potentials were investigated using DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays, along with the CUPRAC (cupric ion reducing antioxidant capacity) method. Furthermore, molecular docking studies of the molecules were performed to investigate ligand-residue interactions in addition to their probable binding modes in the binding site of AChE and BChE enzymes. The results obtained indicate that the synthesized hybrid molecules possess promising anticholinesterase and antioxidant properties and hold potential as therapeutic candidates for the treatment of Alzheimer's disease.
dc.description.sponsorshipInn niversitesi [Idot;nn, University Research Fund (Idot;.. B.A.P. Project No: FLO-2022-3033)]; University Research Fund
dc.description.sponsorshipThis work was supported by the & Idot;nonu University Research Fund (& Idot;.U. B.A.P. Project No: FLO-2022-3033). M. K. would like to extend special thanks to Prof. Dr. Huseyin KARACA from the Department of Chemical Engineering, Faculty of Engineering, & Idot;nonu University, for the use of the laboratory.
dc.identifier.doi10.1002/slct.202506425
dc.identifier.issn2365-6549
dc.identifier.issue6
dc.identifier.orcid0000-0003-4163-9962
dc.identifier.orcid0000-0003-0419-7798
dc.identifier.orcid0000-0003-3547-4209
dc.identifier.orcid0000-0002-9528-6122
dc.identifier.orcid0000-0002-2770-5532
dc.identifier.scopus2-s2.0-105029471206
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1002/slct.202506425
dc.identifier.urihttps://hdl.handle.net/11616/109929
dc.identifier.volume11
dc.identifier.wosWOS:001685090700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subject(benz)imidazol-3-ium salts
dc.subjectantioxidant activity
dc.subjectcholinesterase inhibitors
dc.subjectmolecular docking
dc.subjectQuinoxalin-2(1H)-one
dc.titleSynthesis, Characterization, Anticholinesterase, and Antioxidant Properties of Quinoxalin-2(1H)-One Functionalized (Benz)Imidazol-3-Ium Salts as Hybrid Molecules in Drug Discovery
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu