The impact of hepatic steatosis on epicardial adipose tissue in obese individuals

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dc.contributor.authorTrabzon, Gul
dc.contributor.authorOzturk Keles, Fatma
dc.contributor.authorCaliskan, Osman Firat
dc.contributor.authorGungor, Sukru
dc.contributor.authorYarar, Nuriye
dc.contributor.authorGullu, Ufuk Utku
dc.date.accessioned2026-04-04T13:32:59Z
dc.date.available2026-04-04T13:32:59Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectives This study aimed to evaluate the relationship between epicardial adipose tissue (EAT) thickness and hepatic steatosis in pediatric patients with obesity, exploring EAT as a potential biomarker for cardiovascular risk. Methods A retrospective analysis was conducted on children with obesity aged 10-18, including 48 patients with NAFLD and 50 age- and sex-matched controls with no liver steatosis. EAT thickness was measured using echocardiography, and liver fat was assessed via ultrasound. Correlations between EAT, metabolic parameters, and anthropometric measurements were examined. Results EAT thickness was significantly more excellent in the NAFLD group than in controls (p<0.001), with an optimal cutoff of >1.6 mm predicting hepatic steatosis with 98 % sensitivity and specificity. Positive correlations were found between EAT thickness, body mass index (BMI) Z-scores, and liver steatosis stages. Additionally, structural cardiac changes, such as increased RVDD and IVSd, were observed in the NAFLD group, suggesting early signs of cardiac remodeling. Conclusions EAT thickness may be a non-invasive biomarker for identifying cardiovascular risk in pediatric patients with obesity and NAFLD. Early detection of elevated EAT could guide interventions to reduce obesity-related cardiovascular risk in this population.
dc.identifier.doi10.1515/jpem-2025-0078
dc.identifier.endpage55
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue1
dc.identifier.orcid0009-0007-4991-1955
dc.identifier.orcid0000-0002-5561-3598
dc.identifier.orcid0000-0002-9262-5678
dc.identifier.orcid0000-0003-3430-1162
dc.identifier.pmid41213156
dc.identifier.scopus2-s2.0-105021650832
dc.identifier.scopusqualityQ2
dc.identifier.startpage46
dc.identifier.urihttps://doi.org/10.1515/jpem-2025-0078
dc.identifier.urihttps://hdl.handle.net/11616/108858
dc.identifier.volume39
dc.identifier.wosWOS:001613149100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectepicardial adipose tissue (EAT)
dc.subjectnon-alcoholic fatty liver disease (NAFLD)
dc.subjectpediatric obesity
dc.titleThe impact of hepatic steatosis on epicardial adipose tissue in obese individuals
dc.typeArticle

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