Effect of the Addition of Ketamine to Sevoflurane Anesthesia on Seizure Duration in Electroconvulsive Therapy

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridErdil, Feray Akgül/0000-0002-7544-3717;
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.contributor.authorErdil, Feray
dc.contributor.authorOzgul, Ulku
dc.contributor.authorColak, Cemil
dc.contributor.authorCumurcu, Birgul
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:41:10Z
dc.date.available2024-08-04T20:41:10Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives We evaluated the effects of a subanesthetic dose of ketamine, which was administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile, and recovery times during electroconvulsive therapy in patients with major depression. Methods Patients were randomly allocated to a group receiving either sevoflurane-ketamine (group SK) or sevoflurane-saline (group SS). Sevoflurane was initiated in both groups at 8% for anesthesia induction until loss of consciousness was achieved, at which point it was discontinued. After loss of consciousness, ketamine was administered to the group SK in the form of a 0.5-mg/kg intravenous bolus. Patients in the group SS received saline in the same manner. Mean arterial pressure (MAP) and heart rate were recorded before anesthetic induction (T1); after anesthetic induction (T2); as well as 0, 1, 3, and 10 minutes after the seizure had ended (T3, T4, T5, and T6, respectively). Motor and electroencephalogram seizure durations were recorded. Results Motor and electroencephalogram seizure durations in the group SS were similar to those observed for the group SK. The heart rate increased significantly during T2 to T6 in both group SS and group SK compared with the baseline. The MAP increased in the group SS during the period between T3 and T6 as well as in the group SK during the same period compared with the baseline. The MAP increased more in the group SK, in comparison with the group SS, during T2 (P < 0.05). Conclusions The addition of ketamine at subanesthetic doses, for the purposes of anesthetic induction with sevoflurane, yielded results similar to those in the control group in terms of both seizure duration and hemodynamic stability.en_US
dc.identifier.doi10.1097/YCT.0000000000000225
dc.identifier.endpage185en_US
dc.identifier.issn1095-0680
dc.identifier.issn1533-4112
dc.identifier.issue3en_US
dc.identifier.pmid25719444en_US
dc.identifier.scopus2-s2.0-84940880556en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage182en_US
dc.identifier.urihttps://doi.org/10.1097/YCT.0000000000000225
dc.identifier.urihttps://hdl.handle.net/11616/96969
dc.identifier.volume31en_US
dc.identifier.wosWOS:000360648900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Ecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectelectroconvulsive therapyen_US
dc.subjectseizuresen_US
dc.subjectmajor depressionen_US
dc.subjectsevofluraneen_US
dc.subjectketamineen_US
dc.titleEffect of the Addition of Ketamine to Sevoflurane Anesthesia on Seizure Duration in Electroconvulsive Therapyen_US
dc.typeArticleen_US

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