The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development

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dc.authoridTR53189en_US
dc.authoridTR12656en_US
dc.authoridTR58662en_US
dc.authoridTR37602en_US
dc.authoridTR47257en_US
dc.authoridTR45132en_US
dc.authoridTR201411en_US
dc.authoridTR46811en_US
dc.authoridTR7064en_US
dc.authoridTR34904en_US
dc.contributor.authorÇuğlan, Songül
dc.contributor.authorEkinci, Nihat
dc.contributor.authorYıldız, Azibe
dc.contributor.authorDoğan, Zümrüt
dc.contributor.authorSapmaz, Hilal Irmak
dc.contributor.authorVardı, Nigar
dc.contributor.authorÖzyalın, Fatma
dc.contributor.authorBakırcı, Sinan
dc.contributor.authorÇay, Mahmut
dc.contributor.authorKöse, Evren
dc.contributor.authorTürköz, Yusuf
dc.contributor.authorÖzbağ, Davut
dc.date.accessioned2017-04-11T07:52:28Z
dc.date.available2017-04-11T07:52:28Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was aimed to investigate possible harmful effects of formaldehyde (FA) exposure on the morphology of fetus liver and kidney development during pregnancy and also to determinate possible protective role of chrysin (CH) against these harmful effects. For this aim, after pregnancy was induced, 58 female rats were divided into 6 groups. Serum physiologic (SF) was injected to the Group I rats intraperitoneally (i.p.). 20 mg/kg CH was given to the Group II via gavage. 0.1 mg/kg FA was applied to the Group III (i.p.), 1 mg/kg FA was injected to Group IV (i.p.) 0.1 mg/kg FA was given to Group V i.p., and 20 mg/kg CH was given to the same group via gavage. 1 mg/kg FA was applied to Group VI i.p., and 20 mg/kg CH was given to the same group via gavage. Fetuses were taken from each pregnant rat with cesarean section on the 20th day of the pregnancy. The morphological analyses of the fetuses, liver and kidney; biochemical and histological analyses of the liver and kidney were performed. The fetal body, liver and kidney weight of the FA groups demonstrated a statistically significant decrease the compared to control group. Also the FA-1 group were observed histopathological changes on the fetus liver and kidneys. FA exposure causes harmful effects on fetus the liver and kidneys. CH reduces the negative effect on morphological variables statistically. Although CH is insufficient to fix the histopathological changes that occur in the liver, damaging effects that occur in the kidney decreased statistically.en_US
dc.identifier.citationÇuğlan, S. Ekinci, N. Yıldız, A. Doğan, Z. Sapmaz, H. I. Vardı, N. Özyalın, F. Bakırcı, S. Çay, M. Köse, E. Türköz, Y. Özbağ, D. (2016). The role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney development. Medicine Science | International Medical Journal.en_US
dc.identifier.doi10.5455/medscience.2016.05.8526en_US
dc.identifier.issn2147-0634
dc.identifier.urihttp://www.scopemed.org/?mno=231780
dc.identifier.urihttps://hdl.handle.net/11616/6626
dc.language.isoenen_US
dc.publisherMedicine Science | International Medical Journalen_US
dc.relation.ispartofMedicine Science | International Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFormaldehydeen_US
dc.subjectChrysinen_US
dc.subjectRat fetusesen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.titleThe role of chrysin against harmful effects of formaldehyde exposure on the morphology of rat fetus liver and kidney developmenten_US
dc.typeArticleen_US

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