Role of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (CAPE)

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dc.authoriderdogan, selim/0000-0002-9169-9771
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosiderdogan, selim/AAT-2487-2020
dc.contributor.authorIraz, M
dc.contributor.authorFadillioglu, E
dc.contributor.authorTasdemir, S
dc.contributor.authorErdogan, S
dc.date.accessioned2024-08-04T20:15:11Z
dc.date.available2024-08-04T20:15:11Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.descriptionExperimental Biology 2005 Meeting/35th International Congress of Physiological Sciences -- MAR 31-APR 06, 2005 -- San Diego, CAen_US
dc.description.abstractCaffeic acid phenethyl ester (CAPE) is a phenolic active component of propolis of honeybee hives and reduces heart rate and blood pressure in rats. The objective of this study was to investigate the role of vagal activity and atropine blockage on the bradycardic and hypotensive effects of CAPE in rats. The rats were divided into five groups (n = 8). Saline and vehicle (10% ethanol) of CAPE were given to the first and second groups, respectively. Group 3 was treated with 5 mg/kg CAPE. Group 4 bivagotomized and treated with 5 mg/kg CAPE. Group 5 treated with atropine (5 mu g/mu L/min) continuously and treated with CAPE. The electrophysiological monitoring was done for each experiment under urethane anaesthetize. As a result, CAPE caused intense and transient bradycardia and hypotension. Vagotomy completely abolished bradycardia occurred via CAPE injection; however atropine attenuated bradycardic effects of CAPE. On the other hand, hypotensive effect of CAPE was affected from neither bilateral vagotomy nor atropine treatment. It was thought that CAPE may exert its effects on heart rate via a central parasympathetic control mechanism, but not on central parasympathetic blood pressure control system.en_US
dc.description.sponsorshipAmer Assoc Anatomists,Amer Assoc Immunologists,Amer Physiol Soc,Amer Soc Biochem & Mol Biol,Amer Soc Investigat Pathol,Amer Soc Nutr Sci,Amer Soc Pharmacol & Expt Therapeut,Int Union Physiol Scien_US
dc.identifier.doi10.1385/CT:5:4:391
dc.identifier.endpage396en_US
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.issue4en_US
dc.identifier.pmid16382176en_US
dc.identifier.scopus2-s2.0-29644433959en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://doi.org/10.1385/CT:5:4:391
dc.identifier.urihttps://hdl.handle.net/11616/94206
dc.identifier.volume5en_US
dc.identifier.wosWOS:000237086100005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofCardiovascular Toxicologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl ester (CAPE)en_US
dc.subjectvagotomyen_US
dc.subjectbradycardiaen_US
dc.subjecthypotensionen_US
dc.subjectparasympatheticen_US
dc.subjecthearten_US
dc.titleRole of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (CAPE)en_US
dc.typeConference Objecten_US

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