Morphological Changes and Vascular Reactivity of Rat Thoracic Aorta Twelve Months After Pinealectomy

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dc.authoridyilmaz, zehra/0000-0002-9523-7718
dc.authorwosidyılmaz, zehra/ABF-5526-2020
dc.authorwosidOzturk, Feral/A-2678-2016
dc.contributor.authorKurcer, Zehra
dc.contributor.authorOzturk, Feral
dc.contributor.authorSahna, Engin
dc.contributor.authorKurus, Meltem
dc.contributor.authorOlmez, Ercument
dc.date.accessioned2024-08-04T20:32:23Z
dc.date.available2024-08-04T20:32:23Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Melatonin, a hormone produced by the pineal gland, has been suggested to protect against development of hypertension and atherosclerosis. In this study, the effects of long-term melatonin deficiency for twelve months after pinealectomy on the alpha-adrenergic-contractions induced by phenylephrine, endothelium-dependent relaxation responses to acetylcholine and the morphological changes in the rat thoracic aorta were studied. Material and Metods: Rats were pinealectomized twelve months before the beginning of the vasomotor studies. Rings of arteries were mounted in isolated tissue baths for the measurements of isometric contractile force. The contractile responses to phenylephrine and endothelium-dependent relaxation responses to acetylcholine in the vessels were evaluated. Endothelial function was evaluated by vascular relaxation to acetylcholine. Histological examinations demonstrated the alterations of tunica media in the vessels of pinealectomized rats. Results: Thick and thin areas were observed in the transverse sections of vessels and the ratio of the widest media thickness to the narrowest was found significantly increased in pinealectomized group (2.85 +/- 056) when compared to the control group (1.65 +/- 0.10). In addition, alpha-smooth muscle actin and elastic lamellae staining of the media were attenuated in pinealectomized rats. Although contractile responses of vessels to phenylephrine in pinealectomized rats were lower than control group, significant difference was found for only one concentration (3x 10-8 mol l-1) of phenylephrine. There was no difference between the relaxation responses to acetylcholine in pinealectomized and control groups. Conclusion: These results show that long-term melatonin deficiency may cause some morphological changes in the tunics media of vessels. However, the function of endothelium and vascular responsiveness to proportional to-adrenergic stimulus seem to be mostly protected.en_US
dc.description.sponsorshipInonu University [P-01/33]en_US
dc.description.sponsorshipThis study was supported by a grant from The Scientific Research Fund of Inonu University (P-01/33). We thank Prof Dr. Saim Yologlu for statistical analysis.en_US
dc.identifier.doi10.5336/medsci.2008-9296
dc.identifier.endpage622en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77952900348en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage616en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2008-9296
dc.identifier.urihttps://hdl.handle.net/11616/95044
dc.identifier.volume30en_US
dc.identifier.wosWOS:000277987300025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectaorta, thoracicen_US
dc.subjectratsen_US
dc.titleMorphological Changes and Vascular Reactivity of Rat Thoracic Aorta Twelve Months After Pinealectomyen_US
dc.typeArticleen_US

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