Vitronectin and prolactin levels of cervicovaginal irrigation liquid in preterm birth risk evaluation
| dc.contributor.author | Çoşkun, Ebru İnci | |
| dc.contributor.author | Sezer, Salim | |
| dc.contributor.author | Dağ, İsmail | |
| dc.contributor.author | Yılmaz, Ercan | |
| dc.contributor.author | Ayanoğlu, Yavuz Tahsin | |
| dc.date.accessioned | 2021-03-19T09:35:55Z | |
| dc.date.available | 2021-03-19T09:35:55Z | |
| dc.date.issued | 2020 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Abstract: Aim: The objective of this study is to determine the predictive role of cervical length, cervicovaginal irrigation liquid vitronectin and prolactin levels in preterm birth. Material and Methods: A total of 73 pregnant women between 24-34th gestational week were included and the study population was divided into two groups as: term birth group (n=54) and preterm birth(n=19). Birth weeks, weight and methods were noted. The irrigation fluid has been collected from posterior fornix and vitronectin levels are detected by Enzyme-linked-immunosorbent-assay method. Results: Vitronectin were higher in preterm group as compared to controls [90 (78-98) vs 16 (9-41) ng/ml, p<0.001]. Positive predictive value for vitronectin was 78 %, negative predictive value was 100 % and accuracy ratio was 91.8%. The sensitivity of vitronectin was 100 %, specifity was 89 % with a cut-off value of 59 ng/mL. Area under curve for vitronectin was 0.96 which was compatible with ‘perfect’. When average prolactin levels have been found as 0.14 ng/mL in term and 2 ng/mL in preterm birth group, cervical length have been found as 34.5 and 24.2 mm respectively. Cut-off value for prolactin has been found as 0.088 ng/dL. Positive predictive value was 58.3 % for prolactin and 51.5 % for cervical length. Negative predictive value was 89.8% for prolactin and 95 % for cervical length. Vitronectin was strongly positively correlated with prolactin levels while it was negatively correlated with cervical length (r=0.691 and r=-0.348 respectively). Conclusion: Many trials have been done to make the most accurate prediction of preterm delivery risk. By this study, it makes us think about that vitronectin could be a valuable marker for preterm birth, and also could be independent from the gestational week. | en_US |
| dc.identifier.citation | ÇOŞKUN E. İ,SEZER S,DAĞ İ,YILMAZ E,AYANOĞLU Y. T (2020). Vitronectin and prolactin levels of cervicovaginal irrigation liquid in preterm birth risk evaluation. Annals of Medical Research, 27(1), 360 - 367. Doi: 10.5455/annalsmedres.2019.12.786 | en_US |
| dc.identifier.doi | 10.5455/annalsmedres.2019.12.786 | en_US |
| dc.identifier.endpage | 367 | en_US |
| dc.identifier.issn | 2636-7688 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 360 | en_US |
| dc.identifier.trdizinid | 363431 | en_US |
| dc.identifier.uri | https://doi.org/10.5455/annalsmedres.2019.12.786 | |
| dc.identifier.uri | https://hdl.handle.net/11616/19646 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/yayin/detay/363431 | |
| dc.identifier.volume | 27 | en_US |
| dc.indekslendigikaynak | TR-Dizin | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Vitronectin and prolactin levels of cervicovaginal irrigation liquid in preterm birth risk evaluation | en_US |
| dc.type | Article | en_US |
