Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorOzturk, F
dc.contributor.authorUcar, M
dc.contributor.authorOzturk, IC
dc.contributor.authorVardi, N
dc.contributor.authorBatcioglu, K
dc.date.accessioned2024-08-04T20:13:23Z
dc.date.available2024-08-04T20:13:23Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description6th National Histology and Embryology Congress -- SEP 12-15, 2001 -- ISTANBUL, TURKEYen_US
dc.description.abstractObjectives. To observe the changes in the antioxidative defense enzymes and to detect the alterations of renal microscopy after carbon tetrachloride (CCl4) administration in rats and to investigate the possible protective effects of betaine against CCl4-induced renal damage. Methods. Thirty-two adult Sprague-Dawley rats were divided into four groups as follows: control group, betaine group, CCl4 group, and CCl4 + betaine group. CCl4 was given subcutaneously at 1 mL/kg. In the CCl4 + betaine group, rats were pretreated with betaine, then exposed to CCl4 at the same dose. Betaine group rats received concentrated betaine solution. The rats were killed and the kidneys taken for enzyme analyses and histologic examination. Glutathione peroxidase, superoxide dismutase, and catalase activities were measured in right kidney homogenates. Left kidneys were processed for light microscopic evaluation. Results. In the CCl4-treated group, significant increases in kidney superoxide dismutase and catalase activities and significant decrease in glutathione peroxidase activity were observed (P < 0.01). These changes were found to be normalized in the CCl4 + betaine group. Betaine did not change the enzyme activities. Exposure to CCl4 resulted in glomerular and tubular alterations in the renal cortex. These alterations were found to be prevented by betaine pretreatment. Conclusions. These results indicate that exposure to CCl4 leads to renal damage in rats and betaine exerts an improvement on nephrotoxic effects of CCl4.en_US
dc.identifier.doi10.1016/S0090-4295(03)00255-3
dc.identifier.endpage356en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue2en_US
dc.identifier.pmid12893363en_US
dc.identifier.scopus2-s2.0-0042123515en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage353en_US
dc.identifier.urihttps://doi.org/10.1016/S0090-4295(03)00255-3
dc.identifier.urihttps://hdl.handle.net/11616/93590
dc.identifier.volume62en_US
dc.identifier.wosWOS:000184557200035en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectS-Adenosylmethionineen_US
dc.subjectLiveren_US
dc.subjectGenerationen_US
dc.titleCarbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley ratsen_US
dc.typeConference Objecten_US

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