The status of antimicrobial resistance of Helicobacter pylori in eastern Europe

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dc.authoridBoyanova, Lyudmila/0000-0001-9622-0873
dc.authoridMitov, Ivan/0000-0002-8417-0968
dc.authorwosidBoyanova, Lyudmila/HMW-1231-2023
dc.contributor.authorBoyanova, L
dc.contributor.authorMentis, A
dc.contributor.authorGubina, M
dc.contributor.authorRozynek, E
dc.contributor.authorGosciniak, G
dc.contributor.authorKalenic, S
dc.contributor.authorGöral, V
dc.date.accessioned2024-08-04T20:13:09Z
dc.date.available2024-08-04T20:13:09Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective To evaluate the primary, secondary and combined resistance to five antimicrobial agents of 2340 Helicobacter pylori isolates from 19 centers in 10 countries in eastern Europe. Methods Data were available for centers in Bulgaria, Croatia, the Czech Republic, Estonia, Greece, Lithuania, Poland, Russia, Slovenia and Turkey. Susceptibility was tested by agar dilution (seven countries), E test (five countries) and disk diffusion (three countries) methods. Resistance breakpoints (mg/L) were: metronidazole 8, clarithromycin 1, amoxicillin 0.5, tetracycline 4, and ciprofloxacin 1 or 4 in most centers. Primary and post-treatment resistance was assessed in 2003 and 337 isolates respectively. Results for 282 children and 201 adults were compared. Results Primary resistance rates since 1998 were: metronidazole 37.9%, clarithromycin 9.5%, amoxicillin 0.9%, tetracycline 1.9%, ciprofloxacin 3.9%, and both metronidazole and clarithromycin 6.1%. Isolates from centers in Slovenia and Lithuania exhibited low resistance rates. Since 1998, amoxicillin resistance has been detected in the southeastern region. From 1996, metronidazole resistance increased significantly from 30.5% to 36.4%, while clarithromycin resistance increased slightly from 8.9% to 10.6%. In centers in Greece, Poland, and Bulgaria, the mean metronidazole resistance was slightly higher in adults than in children (39% versus 31.2%, P > 0.05); this trend was not found for clarithromycin or amoxicillin (P > 0.20). Post-treatment resistance rates exhibited wide variations. Conclusions In eastern Europe, primary H. pylori resistance to metronidazole is considerable, and that to clarithromycin is similar to or slightly higher than that in western Europe. Resistance to amoxicillin, ciprofloxacin and tetracycline was detected in several centers. Primary and post-treatment resistance rates vary greatly between centers.en_US
dc.identifier.doi10.1046/j.1469-0691.2002.00435.x
dc.identifier.endpage396en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue7en_US
dc.identifier.pmid12199848en_US
dc.identifier.scopus2-s2.0-0036630233en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.1046/j.1469-0691.2002.00435.x
dc.identifier.urihttps://hdl.handle.net/11616/93425
dc.identifier.volume8en_US
dc.identifier.wosWOS:000176905900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Microbiology and Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectH. pylorien_US
dc.subjecteastern Europeen_US
dc.subjectmetronidazoleen_US
dc.subjectclarithromycinen_US
dc.subjectchildrenen_US
dc.subjectresistanceen_US
dc.titleThe status of antimicrobial resistance of Helicobacter pylori in eastern Europeen_US
dc.typeArticleen_US

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