Lycopene improves activation of antioxidant system and Nrf2/HO-1 pathway of muscle in rainbow trout (Oncorhynchus mykiss) with different stocking densities

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dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidsahin, nurhan/ABF-8007-2020
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorSahin, Kazim
dc.contributor.authorOrhan, Cemal
dc.contributor.authorYazlak, Hasan
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorSahin, Nurhan
dc.date.accessioned2024-08-04T20:39:40Z
dc.date.available2024-08-04T20:39:40Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to describe the effect of lycopene on antioxidant status, heat shock protein 70 (Hsp70), nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme-oxygenase 1(HO-1) levels in the muscle of rainbow trout (Oncorhynchus mykiss). The fish were kept at low(20 kg m(3 - 1)) or high(100 kg m(3 - 1)) stocking densities till the end of study and fed a basal diet or the basal diet supplemented with either 200 or 400 mg of lycopene kg(-1) of diet. The protein, lipid and ash contents in the muscle were not changed by the supplementation of lycopene in rainbow trout kept under high or low stocking densities. In response to increasing supplemental lycopene level, there were linear increases in lycopene levels, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities (P < 0.001) and Nrf2 and HO-1 levels of muscle; linear decreases in muscle malondialdehyde (MDA) and Hsp70 levels (P < 0.001). In conclusion, lycopene supplementation to fish reduces the detrimental effects of oxidative stress and lipid peroxidation resulting from stocking densities via activating host defence system at cellular level. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipUnit of the Scientific Research Projects of Inonu University, Malatya, Turkey; Turkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipThis work was supported by research grants from the Unit of the Scientific Research Projects of Inonu University, Malatya, Turkey. This work was also supported in part by the Turkish Academy of Sciences (TUBA).en_US
dc.identifier.doi10.1016/j.aquaculture.2014.04.007
dc.identifier.endpage138en_US
dc.identifier.issn0044-8486
dc.identifier.issn1873-5622
dc.identifier.scopus2-s2.0-84899701832en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1016/j.aquaculture.2014.04.007
dc.identifier.urihttps://hdl.handle.net/11616/96426
dc.identifier.volume430en_US
dc.identifier.wosWOS:000336564900019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofAquacultureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLycopeneen_US
dc.subjectLipid peroxidationen_US
dc.subjectStocking densityen_US
dc.subjectTrouten_US
dc.titleLycopene improves activation of antioxidant system and Nrf2/HO-1 pathway of muscle in rainbow trout (Oncorhynchus mykiss) with different stocking densitiesen_US
dc.typeArticleen_US

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