Gonarthrosis related changes in quadriceps muscle architecture and physical function outcomes in women

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dc.contributor.authorCiftci, Rukiye
dc.contributor.authorKurtoglu, Ahmet
dc.contributor.authorEken, Ozgur
dc.contributor.authorAldhahi, Monira I.
dc.date.accessioned2026-04-04T13:34:41Z
dc.date.available2026-04-04T13:34:41Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study aimed to assess the effects of gonarthrosis on quadriceps muscle architecture and fatigue, physical function, and postural balance in women compared with healthy controls. Eighty-one females diagnosed with gonarthrosis (n = 40) and healthy control group (n = 41) aged between 47 and 77 years participated in the study. After demographic data were collected, right and left rectus femoris (RF), vastus intermedius (VI), vastus lateralis (VL) thicknesses and RF pennation angle (PA) were determined using a 2D real-time ultrasound device (USG). RF and VI depths and RF cross-sectional area (CSA) were obtained using ultrasound with the probe positioned in a transverse orientation to the muscle. In addition, the participants underwent the timed up and go test (TUG), 30-sec sit-and-up test (SU30s), and completed the Fatigue Severity Scale (FSS). The relationship between functional tests and right and left quadriceps muscle architecture parameters was also analyzed. In our study, the right CSA (p < .001, t=- 8.609, ES = 1.92), left VL (p = .020, t= - 2.365, ES = 0.052), and left CSA (p < .001, t=- 10.164, ES = 2.26) were significantly higher in the healthy group. Conversely, TUG (p < .001, t = 4.882, ES = 1.08) and FSS (p < .001, t = 10.362, ES = 2.29) were significantly higher in the gonarthrosis group, while SU30s values were higher in the control group (p < .001, t = - 12.262, ES = 2.73). Additionally, a negative correlation was observed between SU30s and CSA, whereas TUG and FSS showed a positive correlation with CSA (p < .001). According to the results of our study, some morphological losses were observed in the quadriceps muscle architecture of participants with gonarthrosis. Decreases in CSA affect functional performance. Determination of quadriceps muscle architecture in patients with gonarthrosis can be used to predict functional loss.
dc.description.sponsorshipPNURSP [PNURSP2025R286]; Princess Nourah bint Abdulrahman University; Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
dc.description.sponsorshipWe would like to thank Princess Nourah bint Abdulrahman University for supporting this project through Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R286), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
dc.identifier.doi10.1038/s41598-025-89677-8
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.orcid0000-0002-5255-4860
dc.identifier.orcid0000-0002-5488-3158
dc.identifier.pmid40133373
dc.identifier.scopus2-s2.0-105000966932
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1038/s41598-025-89677-8
dc.identifier.urihttps://hdl.handle.net/11616/109324
dc.identifier.volume15
dc.identifier.wosWOS:001452469400045
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectFatigue Severity Scale
dc.subjectKnee Osteoarthritis
dc.subjectEular Recommendations
dc.subjectMultiple-Sclerosis
dc.subjectStanding Committee
dc.subjectTask-Force
dc.subjectStrength
dc.subjectValidity
dc.subjectReliability
dc.subjectExercise
dc.titleGonarthrosis related changes in quadriceps muscle architecture and physical function outcomes in women
dc.typeArticle

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