Antimicrobial activities of bis-(N-alkylbenzimidazole)-cobalt(II) and zinc (II) complexes

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dc.authoridÜstün, Elvan/0000-0002-0587-7261
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authorwosidÜstün, Elvan/HJB-1157-2022
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.contributor.authorSahin, Neslihan
dc.contributor.authorUstuen, Elvan
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGunal, Selami
dc.contributor.authorOzdemir, Namik
dc.contributor.authorBulbul, Hakan
dc.contributor.authorGurbuz, Nevin
dc.date.accessioned2024-08-04T20:54:40Z
dc.date.available2024-08-04T20:54:40Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEight benzimidazole precursors (L), namely 1-allyl-benzimidazole, 1-methallyl-benzimidazole, 1-isopropyl-benzimidazole, 1-(3-methyloxetan-3-yl)methyl-benzimidazole, 1-allyl-5,6-dimethyl-benzimidazole, 1-methallyl-5,6dimethyl-benzimidazole, 1-isopropyl-5,6-dimethyl-benzimidazole and 1-(3-methyloxetan-3-yl)methyl-5,6dimethyl-benzimidazole, were coordinated to cobalt(II) and zinc(II) cations to form complexes of the type [MCl2L2]. Single-crystal X-ray structures were determined for two cobalt(II) and for one zinc(II) complexes and confirmed their tetrahedral molecular geometry. The antibacterial and antifungal activities of these two series of cobalt(II) and zinc(II) complexes were studied against Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae), Gram-positive (Staphylococcus aureus, methicillin-resistant S. aureus and Enterococcus faecalis) bacteria and fungal strains (Candida albicans and Candida glabrata). Overall, cobalt(II) complexes were more effective than the zinc(II) complexes against all microorganisms. The most significant results were obtained with the two dichloro-bis(1-allyl-5,6-dimethylbenzimidazole)-cobalt(II) and dichloro-bis(1-methallyl-5,6-dimethylbenzimidazole)-cobalt(II) complexes against Candida albicans and Candida glabrata fungi with measured minimal inhibitory concentrations as low as 0.024 mu mol/mL, values close to those obtained with the commercially available drug Flucanozole (0.020 mu mol/mL).en_US
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University [F-461]en_US
dc.description.sponsorshipThis work is supported by the Scientific Research Project Fund of Sivas Cumhuriyet University under the project number F-461.en_US
dc.identifier.doi10.1016/j.inoche.2023.111396
dc.identifier.issn1387-7003
dc.identifier.issn1879-0259
dc.identifier.scopus2-s2.0-85171326063en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2023.111396
dc.identifier.urihttps://hdl.handle.net/11616/101571
dc.identifier.volume157en_US
dc.identifier.wosWOS:001132552300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInorganic Chemistry Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazole liganden_US
dc.subjectCobalten_US
dc.subjectZincen_US
dc.subjectX-ray crystallographyen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntifungal activityen_US
dc.titleAntimicrobial activities of bis-(N-alkylbenzimidazole)-cobalt(II) and zinc (II) complexesen_US
dc.typeArticleen_US

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