N- Phenyl- substituted carbene precursors and their silver complexes: synthesis, characterization and antimicrobial activities

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dc.authoridAlbayrak, Sevil/0000-0002-0253-3746
dc.authoridTahir, Muhammad Nawaz/0000-0002-6815-9806
dc.authoridAkkurt, Mehmet/0000-0003-2421-0929
dc.authoridAkkoc, Senem/0000-0002-1260-9425
dc.authorwosidAlbayrak, Sevil/AAA-2308-2021
dc.authorwosidAkkoç, Senem/AAN-1478-2021
dc.authorwosidTahir, Muhammad Nawaz/F-2900-2015
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidTahir, Muhammad Nawaz/HPB-5726-2023
dc.contributor.authorGok, Yetkin
dc.contributor.authorAkkoc, Senem
dc.contributor.authorAlbayrak, Sevil
dc.contributor.authorAkkurt, Mehmet
dc.contributor.authorTahir, Muhammad Nawaz
dc.date.accessioned2024-08-04T20:38:06Z
dc.date.available2024-08-04T20:38:06Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of unsymmetrically substituted N-heterocyclic carbene (NHC) precursors (1a, 1b, 1c, 1d, 1e) were synthesized from the reaction of N-phenylbenzimidazole with various alkyl halides. These compounds were used to synthesize NHC-silver(I) complexes (2a, 2b, 2c, 2d, 2e). The five new 1-phenyl-3-alkylbenzimidazolium salts (1a, 1b, 1c, 1d, 1e) and their NHC-silver complexes (2a, 2b, 2c, 2d, 2e) were characterized by the H-1 NMR, C-13 NMR and FT-IR spectroscopic methods and elemental analysis techniques. Also, the two NHC-silver complexes 2b and 2c were characterized by single-crystal X-ray crystallography, which confirmed the linear C?Ag?Cl arrangements. The antibacterial activities of the NHC precursor and NHC-silver complexes were tested against three Gram-positive bacterial strains (Bacillus subtilis, Listeria monocytogenes and Staphylococcus aureus) and three Gram-negative bacterial strains (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) using the microdilution broth method. The NHC-silver complexes showed higher antibacterial activity than the NHC precursors. In addition, silver complexes 2a, 2b, 2c, 2d showed high antibacterial activity against the Gram-positive bacteria L. monocytogenes and S. aureus compared to the standard, tetracycline. Copyright (c) 2014 John Wiley & Sons, Ltd.en_US
dc.description.sponsorshipInonu University Research Fund [IUBAP 2011/130]en_US
dc.description.sponsorshipThis work was financially supported by Inonu University Research Fund (IUBAP 2011/130). The authors acknowledge the provision of funds for the purchase of a diffractometer and encouragement by Dr Muhammad Akram Chaudhary, Vice Chancellor, University of Sargodha, Pakistan.en_US
dc.identifier.doi10.1002/aoc.3116
dc.identifier.endpage251en_US
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84897022074en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://doi.org/10.1002/aoc.3116
dc.identifier.urihttps://hdl.handle.net/11616/96387
dc.identifier.volume28en_US
dc.identifier.wosWOS:000333043000007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectbenzimidazolium salten_US
dc.subjectsilver complexen_US
dc.subjectantimicrobial activityen_US
dc.subjectX-ray diffractionen_US
dc.titleN- Phenyl- substituted carbene precursors and their silver complexes: synthesis, characterization and antimicrobial activitiesen_US
dc.typeArticleen_US

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